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1. (WO2014187654) POLYMER DRUG CONJUGATES FOR THE TREATMENT OF AMYLOIDOSIS

Pub. No.:    WO/2014/187654    International Application No.:    PCT/EP2014/058856
Publication Date: Fri Nov 28 00:59:59 CET 2014 International Filing Date: Thu May 01 01:59:59 CEST 2014
IPC: A61K 47/48
A61K 49/00
A61K 49/14
A61K 51/08
A61P 25/28
Applicants: FUNDACION DE LA COMUNIDAD VALENCIANA "CENTRO DE INVESTIGACIONES PRINCIPE FELIPE"
Inventors: VICENT DOCÓN, María Jesús
CONEJOS SANCHEZ, Inmaculada
Title: POLYMER DRUG CONJUGATES FOR THE TREATMENT OF AMYLOIDOSIS
Abstract:
The present invention is referred to novel polymeric conjugates to which at least it is linked a fibril disruptor agent and/or a aggregates blocking agent, and additionally a targeting moiety and/or a probe for therapy and diagnosis. In the polymer-drug conjugate, the polymeric platform transports at least one bioactive agent, selected from the group of anthracyclines antibiotics which includes tetracycline, rolitethracycline, minocycline and/or doxycycline and their derivatives, etc..., able to disaggregate or break the amyloid fibrils and/or block the aggregates. This conjugate could contain in its structure one or several targeting moieties, which will provide an effective targeting of the polymer-drug conjugate to the selected diseased area for drug activity, increasing the therapeutic efficacy in the treatment of amyloidosis related diseases, including amyloidosis related to polyneuropathic disorders and neurodegenerative diseases like FAP and AD.