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1. (WO2014187269) METHOD FOR PRODUCING DIMERIZED FUSION PROTEIN BY FERMENTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/187269    International Application No.:    PCT/CN2014/077618
Publication Date: 27.11.2014 International Filing Date: 15.05.2014
IPC:
C12N 15/62 (2006.01), C12N 15/81 (2006.01), C12N 1/19 (2006.01), C12P 21/02 (2006.01), C07K 19/00 (2006.01), C12R 1/84 (2006.01)
Applicants: LANZHOU UNIVERSITY [CN/CN]; Chengguan District, South Tianshui Road 222, Tianyan Building Room 213 Lanzhou, Gansu 730000 (CN)
Inventors: LI, Hongyu; (CN).
AN, Lizhe; (CN).
ZHI, Dejuan; (CN).
LI, Yang; (CN).
FENG, Na; (CN).
GUO, Dingding; (CN).
WANG, Yong; (CN).
SHI, Yanbin; (CN).
RU, Yi; (CN).
WANG, Meizhu; (CN).
TANG, Wei; (CN).
GAO, Jiangli; (CN).
HOU, Rongli; (CN).
XU, Jing; (CN).
XIAN, Jun; (CN).
XU, Yinli; (CN).
ZHANG, Liyun; (CN).
WANG, Haiqing; (CN).
DONG, Xinfang; (CN).
MA, Xingming; (CN).
LI, Jiazhong; (CN).
ZHU, Hongmei; (CN).
LI, Jianyin; (CN).
ZHAO, Chunyan; (CN)
Priority Data:
201310084035.3 15.03.2013 CN
Title (EN) METHOD FOR PRODUCING DIMERIZED FUSION PROTEIN BY FERMENTATION
(FR) PROCÉDÉ DE PRODUCTION D'UNE PROTÉINE DE FUSION DIMÉRISÉE PAR FERMENTATION
(ZH) 发酵生产二聚体化融合蛋白的方法
Abstract: front page image
(EN)Construction and fermentation of dimerized thrombopoietin (TPO) mimetic peptide (TMP) diad-human serum albumin (HSA) fusion protein. The fusion protein contains one HSA and two TPO mimetic peptides that are connected by means of a short connecting peptide and a dimerization domain.
(FR)L'invention concerne la construction et la fermentation d'une protéine de fusion dimérisée sérum-albumine humaine (HSA)-diade peptide mimétique de la thrombopoïétine (TPO) (TMP). La protéine de fusion contient une HSA et deux peptides mimétiques de TPO qui sont reliés au moyen d'un peptide de liaison court et un domaine de dimérisation.
(ZH)本发明提供了二聚体化促血小板生成素(TPO)模拟肽TMP二联体-人血清白蛋白融合蛋白的构建及发酵。所述融合蛋白包含1个HSA和2个TPO模拟肽通过连接短肽及二聚体化结构域连接。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)