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1. (WO2014186877) FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/186877    International Application No.:    PCT/CA2014/000457
Publication Date: 27.11.2014 International Filing Date: 26.05.2014
IPC:
C07K 14/705 (2006.01), A61K 39/00 (2006.01), A61K 39/395 (2006.01), A61K 47/48 (2006.01), A61P 37/04 (2006.01), C07K 16/28 (2006.01), G01N 33/566 (2006.01)
Applicants: PROMIS NEUROSCIENCES INC. [CA/CA]; (CA)
Inventors: UGER, Marni Diane; (CA).
CIOLFI, Veronica; (CA).
CASHMAN, Neil R.; (CA)
Agent: BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; 40th Floor 40 King Street West, Scotia Plaza Toronto, Ontario M5H 3Y2 (CA)
Priority Data:
61/827,255 24.05.2013 US
Title (EN) FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
(FR) ANTICORPS DIRIGÉS CONTRE LE RÉCEPTEUR FAS À USAGE DIAGNOSTIQUE ET THÉRAPEUTIQUE
Abstract: front page image
(EN)Provided herein are an exogenous antibody that binds selectively to a misfolded form of human FasR, and methods and uses for said antibody. Specifically disclosed is the antibody designated AMF 3a-118 which selectively binds the peptide represented by LHHDGQFCH (SEQ ID NO:2) and the antibody designated AMF 3d-19 which selectively binds the peptide represented by NSTVCEH (SEQ ID NO:5).
(FR)L'invention concerne un anticorps exogène qui se lie sélectivement à une forme mal repliée du récepteur Fas humain, ainsi que des procédés et des utilisations associés à cet anticorps. L'invention concerne en particulier l'anticorps appelé AMF 3a-118 qui se lie sélectivement au peptide représenté par LHHDGQFCH (SEQ ID NO:2) et l'anticorps appelé AMF 3d-19 qui se lie sélectivement au peptide représenté par NSTVCEH (SEQ ID NO:5).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)