WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
1. (WO2014186798) RECEPTORS FOR B7-H4
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/186798    International Application No.:    PCT/US2014/038623
Publication Date: 20.11.2014 International Filing Date: 19.05.2014
G01N 33/564 (2006.01), A61K 38/00 (2006.01), A61K 39/00 (2006.01), G01N 33/68 (2006.01)
Applicants: AMPLIMMUNE, INC. [US/US]; 45 W. Watkins Mills Road Gaithersburgh, MD 21201 (US)
Inventors: LANGERMANN, Solomon; (US).
PODOJIL, Joseph R.; (US).
MILLER, Stephen D.; (US)
Agent: VORNDRAN, Charles; Pabst Patent Group LLP 1545 Peachtree Street, NE Suite 320 Atlanta, GA 30309 (US)
Priority Data:
61/824,860 17.05.2013 US
Abstract: front page image
(EN)Isolated cell surface receptors for B7-H4 have been identified based on function. B7-H4 receptor activation by B7-H4 on the dendritic cell, T follicular helper cell and germinal center B cell membrane stimulates inhibitory signaling in those leukocytes. B7-H4 receptor activation decreases production and/or secretion of proinflammatory cytokines, and promotes anti-inflammatory cytokine by mature DC and T cells. Modulators of B7-H4 receptor polypeptides and methods for their therapeutic use are also provided.
(FR)Selon l'invention, des récepteurs de surface cellulaire isolés pour B7-H4 ont été identifiés sur la base de la fonction. L'activation des récepteurs de B7-H4 par les B7-H4 sur la cellule dendritique, le lymphocyte T auxiliaire folliculeux et la membrane cellulaire à centre germinatif B stimule la signalisation inhibitrice dans ces leucocytes. L'activation des récepteurs de B7-H4 diminue la production et/ou la sécrétion des cytokines pro-inflammatoires, et favorise la cytokine anti-inflammatoire par les cellules DC et T matures. L'invention concerne également des modulateurs des polypeptides des récepteurs de B7-H4 et des procédés pour leur utilisation thérapeutique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)