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1. (WO2014186649) COMPOSITIONS AND METHODS FOR TREATING HIV-1-ASSOCIATED CHRONIC IMMUNE ACTIVATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/186649    International Application No.:    PCT/US2014/038310
Publication Date: 20.11.2014 International Filing Date: 16.05.2014
IPC:
A61K 48/00 (2006.01), C12N 15/113 (2010.01), C12N 15/115 (2010.01)
Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US/US]; 330 Brookline Avenue Boston, MA 02215 (US)
Inventors: BERNARD, Mark, A.; (US).
TACHADO, Souvenir, D.; (US)
Agent: LU, Yu; (US)
Priority Data:
61/824,764 17.05.2013 US
61/876,832 12.09.2013 US
61/933,393 30.01.2014 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING HIV-1-ASSOCIATED CHRONIC IMMUNE ACTIVATION
(FR) COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE L'ACTIVATION IMMUNITAIRE CHRONIQUE ASSOCIÉE AU VIH
Abstract: front page image
(EN)The invention provides compositions and methods for treating HIV-associated chronic immune activation in HIV-positive patients, or for preventing the same in patients at risk of being infected by HIV. The compositions of the invention include antagomirs that antagonize the function of certain HIV-derived viral microRNA (vmiR), which vmiR may lead to chronic immune activation in HIV-positive patients by non-canonical activation of certain pro-inflammatory cytokine pathways.
(FR)La présente invention concerne des compositions et des procédés permettant de traiter une activation immunitaire chronique associée au VIH chez des patients positifs au HIV ou permettant de la prévenir chez des patients présentant un risque d'infection par le VIH. Les compositions de l'invention comprennent des antagomirs qui ont une action antagoniste contre la fonction de certains microARN viraux dérivés du VIH (vmiR), lesdits vmiR pouvant mener à une activation immunitaire chronique chez des patients positifs au VIH par l'activation non canonique de certaines voies de cytokines pro-inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)