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1. (WO2014186361) PHARMACOGENOMIC BIOMARKERS FOR B CELL MALIGNANCIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/186361    International Application No.:    PCT/US2014/037848
Publication Date: 20.11.2014 International Filing Date: 13.05.2014
IPC:
C07K 14/715 (2006.01)
Applicants: CHEN, Wei [US/US]; (US)
Inventors: CHEN, Wei; (US)
Agent: VIDAS, Scott; (US)
Priority Data:
61/823,246 14.05.2013 US
Title (EN) PHARMACOGENOMIC BIOMARKERS FOR B CELL MALIGNANCIES AND METHODS OF USE THEREOF
(FR) BIOMARQUEURS PHARMACOGÉNOMIQUES POUR LES TUMEURS MALIGNES À LYMPHOCYTES B ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Abstract: front page image
(EN)The present invention relates to the discovery that deletion and mutation of the IL10RA gene on chromosome 11q23 avert CpG ODN drug-induced apoptosis of human B-CLL cells. The IL10RA gene encodes a protein IL-10R1 precursor, where the IL-10R1 precursor contains a 21 amino acid signal peptide at the N-terminal. IL-10R1 precursor turns into IL-10R1 by posttranslational modification after the 21 amino acid signal peptide is cleaved off. These new biomarkers are useful as pharmacogenomic biomarker classifiers. These biomarkers can be used to select, stratify, or exclude patients with B cell malignancies for certain therapies and can be used to predict clinical outcomes.
(FR)La présente invention concerne le diagnostic de la leucémie lymphoïde chronique (LLC) résistant aux médicaments chez un mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)