Publication Number
WO/2014/185805
Publication Date
20.11.2014
International Application No.
PCT/PT2014/000032
International Filing Date
15.05.2014
Applicants
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INSTITUTO SUPERIOR TECNICO
[PT]/[PT]
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LABORATÓRIO NACIONAL DE ENERGIA E GEOLOGIA
[PT]/[PT]
Inventors
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FONSECA, César Simões da
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FARIA, Nuno Ricardo
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FERREIRA, Frederico Castelo Alves
Agents
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OLIVEIRA, Arlindo Manuel Limede de
Publication Language
English (en)
Filing Language
English (en)
Designated States
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Title
(EN) ENZYMATIC PROCESS FOR THE PRODUCTION OF MANNOSYLERYTHRITOL LIPIDS FROM LIGNOCELLULOSIC MATERIALS
(FR) PROCÉDÉ ENZYMATIQUE POUR LA PRODUCTION DE LIPIDES MANNOSYLÉRYTHRITOL, À PARTIR DE MATÉRIAUX LIGNOCELLULOSIQUES
Abstract
(EN) The present invention relates to processes for the production of microbial glycolipids, mannosylerythritol lipids (MEL), from lignocellulosic carbon source. These processes are characterized in that the use of lignocellulosic materials for the production of a microbial glycolipids, MEL, comprising a fermentation preferably using fungi of the genus Pseudozyma or other microorganisms such as genetically modified fungi or bacteria. The processes for production of microbial glycolipids, MEL comprise three steps: pretreatment of lignocellulosic material; enzymatic hydrolysis; and. fermentation. The enzymatic hydrolysis and fermentation may take place sequentially or simultaneously with addition of exogenous enzymes or simultaneously with enzymes produced by the microorganism itself. The produced microbial glycolipids have applications as: biosurfactants; antimicrobials; anticancer agents; wound healing factors; stabilizer agents on storage and purification of proteins or vaccines; drugs and gene deliver agents; antifreeze agents.
(FR) La présente invention concerne des procédés de production de glycolipides microbiens, les lipides mannosylérythritol (LME), à partir d'une source carbonée lignocellulosique. Ces procédés se caractérisent par l'utilisation de matériaux lignocellulosiques pour la production de glycolipides microbiens, LME, et comprennent une fermentation employant de préférence un champignon du genre Pseudozyma ou d'autres micro-organismes comme des champignons ou des bactéries génétiquement modifiés. Les procédés de production de glycolipides microbiens LME comprennent trois étapes : prétraitement de matériau lignocellulosique, hydrolyse enzymatique et fermentation. L'hydrolyse enzymatique et la fermentation ont lieu successivement ou simultanément avec l'addition d'enzymes exogènes ou simultanément avec des enzymes produites par le micro-organisme lui-même. Les glycolipides microbiens produits ont des applications comme tensioactifs, antimicrobiens, agents anticancéreux, facteurs de cicatrisation des plaies, agents stabilisants en stockage et purification de protéines ou de vaccins, médicaments et agent de délivrance de gènes, agents antigel.
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