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1. (WO2014183520) THIOPHENE MIAZINES DERIVATE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/183520    International Application No.:    PCT/CN2014/075387
Publication Date: 20.11.2014 International Filing Date: 15.04.2014
IPC:
C07D 471/04 (2006.01), A61K 31/519 (2006.01), A61P 31/12 (2006.01), A61P 25/00 (2006.01), A61P 35/00 (2006.01)
Applicants: SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN/CN]; 279 Wenjing Road, Minhang District Shanghai 200245 (CN).
JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047 (CN)
Inventors: LI, Xin; (CN).
SUN, Piaoyang; (CN).
LAN, Jiong; (CN).
PENG, Jianbiao; (CN).
CHEN, Yang; (CN).
WANG, Bin; (CN).
DONG, Qing; (CN)
Agent: GE CHENG & CO., LTD.; Level 19, Tower E3, The Towers, Oriental Plaza No.1, East Chang An Avenue, Dongcheng District Beijing 100738 (CN)
Priority Data:
201310183029.3 17.05.2013 CN
Title (EN) THIOPHENE MIAZINES DERIVATE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF
(FR) DÉRIVÉ DE MIAZINES DE TIOPHÈNE, SON PROCÉDÉ DE PRÉPARATION ET SES APPLICATIONS MÉDICALES
(ZH) 吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用
Abstract: front page image
(EN)Provided are a thiophene miazines derivate with a general formula (I), a pharmaceutical salt thereof, a preparation method therefor, and an application for being used as a therapeutical agent for treating a cancer and particularly used as a CDK4 and/or CDK6 inhibitor, definitions of substituent groups in the general formula (I) being same as definitions in the specification.
(FR)L'invention concerne un dérivé de miazines de tiophène de formule générale (I), un sel pharmaceutique de celui-ci, son procédé de préparation, et une application pour son utilisation en tant qu'agent thérapeutique pour traiter un cancer et utilisé en particulier comme inhibiteur de CDK4 et/ou CDK6, les groupes substituants de la formule générale (I) étant tels que définis dans la description.
(ZH)提供一种通式(I)所示吡啶并嘧啶类衍生物及其可药用盐,其制备方法以及它们作为癌症治疗剂特别是作为CDK4和/或CDK6抑制剂的用途,其中通式(I)中的各取代基的定义与说明书中的定义相同。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)