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1. (WO2014183110) METHODS FOR THE DETECTION OF BRAIN INJURY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/183110    International Application No.:    PCT/US2014/037675
Publication Date: 13.11.2014 International Filing Date: 12.05.2014
IPC:
A61K 49/00 (2006.01), A61P 43/00 (2006.01)
Applicants: THE UNIVERSITY OF MONTANA [US/US]; 32 Campus Drive Missoula, MT 59812 (US)
Inventors: PATEL, Sarjubhai, A.; (US).
RAU, Thomas, F.; (US)
Agent: SCOTT, Zachary A.; Minerva, PLLC 269 West Front Street Missoula, MT 59802 (US)
Priority Data:
61/822,034 10.05.2013 US
Title (EN) METHODS FOR THE DETECTION OF BRAIN INJURY
(FR) PROCEDES DE DETECTION D'UNE LESION CEREBRALE
Abstract: front page image
(EN)The invention provides methods for the detection of brain injury, such as traumatic brain injury (TBE) or chronic traumatic encephalopathy (CTE), in a patient (e.g., a human) that has suffered or is at risk of suffering one or more traumatic events. The methods of the invention measure, through non-invasive or invasive means, the expression of System xc- cystine/glutamate transporter expression in patient tissue (e.g., neuronal tissue). The loss of System xc- cystine/glutamate transporter expression is correlated with brain injury, severity, and disease progression.
(FR)L'invention concerne des procédés pour la détection d'une lésion cérébrale, telle qu'une lésion cérébrale (TBE) ou une encéphalopathie traumatique chronique (CTE), chez un patient (par exemple, un être humain) qui a trop souffert ou présente un risque de souffrir d'un ou de plusieurs évènements traumatiques. Les procédés de l'invention mesurent, par des moyens non-invasifs ou invasifs, l'expression d u système xc expression du transporteur cystine/glutamate dans le tissu du patient (par exemple tissu neuronal). La perte du Système xc expression du transporteur cystine/glutamate est corrélée à la lésion cérébrale, la gravité et la progression de la maladie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)