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1. (WO2014183066) PROTEIN MODIFICATION OF LIVING CELLS USING SORTASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/183066    International Application No.:    PCT/US2014/037545
Publication Date: 13.11.2014 International Filing Date: 09.05.2014
IPC:
C12N 9/48 (2006.01)
Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US/US]; Nine Cambridge Center Cambridge, MA 02142 (US)
Inventors: SWEE, Lee, Kim; (US).
PLOEGH, Hidde, L.; (US)
Agent: BAKER, C., Hunter; (US)
Priority Data:
61/943,094 21.02.2014 US
61/822,092 10.05.2013 US
Title (EN) PROTEIN MODIFICATION OF LIVING CELLS USING SORTASE
(FR) MODIFICATION PROTÉIQUE DE CELLULES VIVANTES À L'AIDE DE SORTASE
Abstract: front page image
(EN)Non-genetically engineered mammalian cells modified by sortase-mediated conjugation of an agent thereto are provided. Methods of conjugating agents to nongenetically engineered mammalian cells using sortase are provided. Methods of using the cells, e.g. a method of modulating an immune response of a subject to an entity of interest, a method of neutralizing a substance in the body of a subject, a method of treating a subject in need of treatment for deficiency of a protein, and a method of treating a subject in need of treatment for a disease, are provided.
(FR)L'invention concerne des cellules de mammifères non génétiquement manipulées modifiées par conjugaison médiée par sortase d'un agent sur ces dernières. L'invnetion concerne des méthodes de conjugaison d'agents à des cellules de mammifères non génétiquement manipulées à l'aide de sortase. L'invention concerne des méthodes d'utilisation de cellules, par ex., à des fins diagnostiques et/ou thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)