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Machine translation
1. (WO2014183052) SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/183052    International Application No.:    PCT/US2014/037520
Publication Date: 13.11.2014 International Filing Date: 09.05.2014
IPC:
A61K 39/395 (2006.01), C07K 16/08 (2006.01), G01N 33/569 (2006.01), A61P 31/12 (2006.01), A61P 31/14 (2006.01), C07K 16/10 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPART OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard Suite 325, MSC 7660 Bethesda, MD 20852-7600 (US).
INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA [AR/AR]; Rivadavia 1439 Ciudad Autonoma de Buenos Aires, 1033 (AR)
Inventors: BOK, Karin; (US).
GARAICOECHEA, Lorena, Laura; (AR).
PARRENO, Viviana; (AR).
AGUILAR, Andrea, Pamela; (AR).
BOK, Marina; (AR).
GREEN, Lisbeth, Kim; (US).
SOSNOVTSEV, Stanislav, Vladimirovich; (US)
Agent: SIEGEL, Susan, Alpert; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Priority Data:
61/821,354 09.05.2013 US
Title (EN) SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE
(FR) ANTICORPS VHH À DOMAINE UNIQUE DIRIGÉ CONTRE LES NOROVIRUS GI.1 ET GII.4 ET LEUR UTILISATION
Abstract: front page image
(EN)Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
(FR)L'invention concerne des anticorps monoclonaux isolés VHH qui se lient spécifiquement à un polypeptide de norovirus. Dans certains modes de réalisation, le norovirus est un norovirus de génogroupe I ou un norovirus de génogroupe II. Dans d'autres modes de réalisation, le norovirus est un virus Norwalk ou un virus MD2004. Dans d'autres modes de réalisation, les anticorps monoclonaux se lient spécifiquement à VP1. L'invention concerne également des compositions comprenant les anticorps précités, des acides nucléiques codant pour ces anticorps, des vecteurs d'expression comprenant les acides nucléiques et des cellules hôtes isolées qui expriment les acides nucléiques. Les anticorps et les compositions précités peuvent être utilisés pour détecter la présence d'un norovirus dans un échantillon biologique ou détecter une infection par un norovirus infection. L'invention concerne également des méthodes pour traiter et/prévenir une infection par NoV infection.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)