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1. (WO2014182945) ACC INHIBITORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/182945    International Application No.:    PCT/US2014/037363
Publication Date: 13.11.2014 International Filing Date: 08.05.2014
IPC:
A61K 31/517 (2006.01), A61K 31/4375 (2006.01)
Applicants: NIMBUS APOLLO, INC. [US/US]; 25 First Street, Suite 404 Cambridge, Massachusetts 02141 (US)
Inventors: GREENWOOD, Jeremy Robert; (US).
HARRIMAN, Geraldine C.; (US).
BORG, George; (US).
MASSE, Craig E.; (US)
Agent: MCLEAN, Thomas H.; (US)
Priority Data:
61/821,828 10.05.2013 US
Title (EN) ACC INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DE L'ACC ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same. Specifically, bicyclic heteroaryl derivatives containing a imidazole, thiazole or oxazole fused to a pyridinone, pyrimidinone or pyrimidindione are provided. These compounds have therapeutic utility toward treating an ACC enzyme mediated disorder such as obesity in a subject, upon administration in an effective amount to said subject.
(FR)Cette invention concerne des composés utiles en tant qu'inhibiteurs de l'acétyl-CoA carboxylase (ACC), des compositions de ceux-ci, et leurs méthodes d'utilisation. Spécifiquement, des dérivés d'hétéroaryle bicyclique contenant un imidazole, thiazole ou oxazole fusionné à une pyridinone, pyrimidinone ou pyrimidindione sont divulgués. Ces composés présentent une utilité thérapeutique vis-à-vis du traitement d'un trouble médié par l'enzyme ACC tel que l'obésité chez un sujet, par l'administration en quantité efficace audit sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)