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1. (WO2014182532) MESOTHELIN-SPECIFIC IMMUNOCYTOKINE AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/182532    International Application No.:    PCT/US2014/036296
Publication Date: 13.11.2014 International Filing Date: 01.05.2014
IPC:
A61K 47/48 (2006.01), A61K 39/00 (2006.01)
Applicants: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes Of Health Office Of Technology Transfer 6011 Executive Boulevard Suite 325, Msc 7660 Bethesda, MD 20852-7660 (US)
Inventors: HO, Mitchell; (US).
PASTAN, Ira, H.; (US).
KIM, Heungnam; (US)
Agent: CONNOLLY, Jodi, L.; Klarquist Sparkman, L.L.P One World Trade Center, Suite 1600 121 Sw Salmon Street Portland, OR 97204 (US)
Priority Data:
61/820,543 07.05.2013 US
Title (EN) MESOTHELIN-SPECIFIC IMMUNOCYTOKINE AND USE THEREOF
(FR) IMMUNOCYTOKINE SPÉCIFIQUE DE LA MÉSOTHÉLINE ET SON UTILISATION
Abstract: front page image
(EN)Described herein is the development of an immunocytokine based on interleukin-12 (IL12) and the mesothelin-specific SS1 Fv. The IL12-SS1 (Fv) immunocytokine was produced in insect cells using a baculovirus expression system. The SS1 single-chain Fv was fused to the C terminus of the p35 subunit of IL12 through a short linker. The single-chain IL12-SS1 (Fv) immunocytokine binds native mesothelin proteins on mesothelioma and ovarian cancer cells, as well as recombinant mesothelin. The recombinant immunocytokine retains sufficient bioactivity of IL12 and significantly inhibits human malignant mesothelioma in an animal model.
(FR)L'invention concerne le développement d'une immunocytokine basée sur l'interleukine-12 (IL12) et le fragment Fv de SSI spécifique de la mésothéline. L'immunocytokine IL12-SS1 (Fv) est produite dans des cellules d'insecte en utilisant un système d'expression de baculovirus. Le fragment Fv à chaîne simple de SSI est hybridé à l'extrémité C de la sous-unité p35 de l'IL12 par un lieur court. L'immunocytokine à chaîne simple IL12-SS1 (Fv) se lie aux protéines de la mésothéline native sur les cellules du mésothéliome et les cellules du cancer des ovaires, ainsi que la mésothéline recombinée. L'immunocytokine recombinée conserve une bioactivité de l'IL12 suffisante et inhibe significativement le mésothéliome malin chez l'homme dans un modèle animal.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)