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1. (WO2014182051) COMPOSITION COMPRISING ASM INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DEGENERATIVE NEUROLOGICAL DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/182051    International Application No.:    PCT/KR2014/004025
Publication Date: 13.11.2014 International Filing Date: 07.05.2014
IPC:
A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61P 25/28 (2006.01), A61P 25/16 (2006.01)
Applicants: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; (Sangyeok-dong), 80, Daehak-ro Buk-gu Daegu 702-701 (KR)
Inventors: BAE, Jae Sung; (KR).
JIN, Hee Kyung; (KR).
LEE, Jong Kil; (KR)
Agent: KIM, Soon Woong; 601, (Guro- dong) 20, Digital-ro 31-gil Guro-gu Seoul 152-766 (KR)
Priority Data:
10-2013-0051279 07.05.2013 KR
Title (EN) COMPOSITION COMPRISING ASM INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DEGENERATIVE NEUROLOGICAL DISORDERS
(FR) COMPOSITION COMPRENANT UN INHIBITEUR ASM COMME PRINCIPE ACTIF POUR PRÉVENIR OU TRAITER DES TROUBLES NEUROLOGIQUES DÉGÉNÉRATIFS
(KO) ASM 억제제를 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a composition comprising an ASM inhibitor as an active ingredient for preventing or treating degenerative neurological diseases. According to the present invention, when ASM is partially removed in an Alzheimer's disease model mouse, that is when ASM is inhibited therein, such when as an Alzheimer's disease model mouse with a partial removal of ASM is in a parabionic union with an Alzheimer's disease model mouse, or when an Alzheimer's disease model mouse is injected with the serum of an Alzheimer's disease model mouse from which ASM gene has been removed, the deposition of β-amyloid in the brain tissue is inhibited and the ability to learn and remember are improved, and the present invention confirms such superb effects. Accordingly, ASM inhibitor can be effectively used to prevent or treat degenerative neurological diseases.
(FR)La présente invention concerne une composition comprenant un inhibiteur ASM comme principe actif pour prévenir ou traiter des maladies neurologiques dégénératives. Selon la présente invention, lorsqu'un ASM est partiellement éliminé chez une souris modèle atteinte de la maladie d'Alzheimer, c'est-à-dire lorsqu'un ASM est inhibé dans celle-ci, par exemple lorsqu'une souris modèle atteinte de la maladie d'Alzheimer ayant une élimination partielle d'ASM est en union para-bionique avec une souris modèle atteinte de la maladie d'Alzheimer, ou lorsqu'une souris modèle atteinte de la maladie d'Alzheimer est injectée avec le sérum d'une souris modèle atteinte de la maladie d'Alzheimer à partir de laquelle un gène ASM a été éliminé, le dépôt de β-amyloïde dans le tissu cérébral est inhibé et les capacités à apprendre et à se souvenir sont améliorées, et la présente invention confirme de tels superbes effets. Par conséquent, un inhibiteur ASM peut être utilisé efficacement pour prévenir ou traiter des maladies neurologiques dégénératives.
(KO)본 발명은 ASM 억제제를 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따르면, 알츠하이머병 모델 마우스에 ASM을 부분적으로 결손시킨 경우, ASM 유전자가 부분적으로 결손된 마우스와 알츠하이머병 모델 마우스를병체 결합시킨 모델의 경우 및 ASM 유전자가 결손된 마우스의 혈청을 알츠하이머병 모델 마우스에 주입한 경우 등, 알츠하이머병 모델 마우스에서 ASM을 억제하였을 때, 뇌 조직 내 β-아밀로이드의 침착이 저해되고, 학습 및 기억력이 개선되는 우수한 효과가 있음을 확인하였다. 따라서, ASM 억제제는 알츠하이머병을 비롯한 퇴행성 신경질환의 예방 또는 치료에 유용하게 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)