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1. (WO2014181368) AQUEOUS OPHTHALMIC FORMULATIONS BASED ON AZITHROMYCIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/181368    International Application No.:    PCT/IT2014/000120
Publication Date: 13.11.2014 International Filing Date: 06.05.2014
IPC:
A61K 9/00 (2006.01), A61K 47/48 (2006.01), A61K 31/7052 (2006.01)
Applicants: MEDIVIS S.r.l. [IT/IT]; Corso Italia, 171 I-95127 Catania (IT)
Inventors: ALEO, Danilo; (IT).
SAITA, Maria Grazia Antonietta; (IT).
MELILLI, Barbara; (IT).
MANGIAFICO, Sergio; (IT).
CRO, Melina; (IT)
Agent: BANCHETTI, Marina; Barzano' & Zanardo Roma S.p.A. Via Piemonte, 26 I-00187 Roma (IT)
Priority Data:
RM2013A000268 06.05.2013 IT
Title (EN) AQUEOUS OPHTHALMIC FORMULATIONS BASED ON AZITHROMYCIN
(FR) FORMULATIONS OPHTALMIQUES AQUEUSES À BASE D'AZITHROMYCINE
Abstract: front page image
(EN)The invention concerns topical ophthalmic preparations in the form of eye-drops in aqueous solution, containing azithromycin (or a pharmacologically acceptable salt thereof) as active ingredient, wherein the azithromycin is solubilized and stabilized by means of β-cyclodextrins, and in particular by means of the β-cyclodextrin called sulfobutyl ether β-cyclodextrin (SBE-P-CD). The proposed preparations have a remarkably high stability, both physical and chemical, which enables its storage at room temperature for the envisaged period of validity for a commercial pharmaceutical product.
(FR)Cette invention concerne des préparations ophtalmiques topiques sous la forme de gouttes oculaires en solution aqueuse, contenant de l'azithromycine (ou un sel pharmaceutiquement acceptable de celle-ci) à titre de principe actif, l'azithromycine étant solubilisée et stabilisée au moyen de β-cyclodextrines, et en particulier au moyen de la β-cyclodextrine appelée sulfobutyle éther β-cyclodextrine (SBE-P-CD). Les préparations proposées ont une stabilité, à la fois physique et chimique, remarquablement élevée qui permet leur stockage à température ambiante pour la période de validité envisagée pour un produit pharmaceutique commercial.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)