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1. (WO2014181252) COMBINATION OF A PI3 KINASE INHIBITOR WITH PACLITAXEL FOR USE IN THE TREATMENT OR PREVENTION OF A CANCER OF THE HEAD AND NECK
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/181252    International Application No.:    PCT/IB2014/061239
Publication Date: 13.11.2014 International Filing Date: 06.05.2014
IPC:
A61K 31/337 (2006.01), A61K 31/506 (2006.01), A61P 35/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HIRAWAT, Samit [US/US]; (US) (US only).
MASSACESI, Cristian [IT/FR]; (FR) (US only).
DI TOMASO, Emmanuelle [FR/US]; (US) (US only)
Inventors: HIRAWAT, Samit; (US).
MASSACESI, Cristian; (FR).
DI TOMASO, Emmanuelle; (US)
Agent: LYNCH, Jim; c/o NOVARTIS PHARMACEUTICALS CORPORATION One Health Plaza East Hanover, New Jersey 07936 (US)
Priority Data:
13/54211 07.05.2013 FR
Title (EN) COMBINATION OF A PI3 KINASE INHIBITOR WITH PACLITAXEL FOR USE IN THE TREATMENT OR PREVENTION OF A CANCER OF THE HEAD AND NECK
(FR) COMBINAISON D'UN INHIBITEUR DE P13 KINASE ET DE PACLITAXEL À UTILISER DANS LE TRAITEMENT OU LA PRÉVENTION D'UN CANCER DE LA TÊTE ET DU COU
Abstract: front page image
(EN)A pharmaceutical combination comprising (a) a phosphatidylinositol-3-kinase (PI3K) inhibitor compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof and (b) paclitaxel or a pharmaceutically acceptable salt thereof for simultaneous, separate or sequential use, for the treatment of a cancer of the head and neck; a pharmaceutical composition comprising said combination; the use of said combination for the preparation of a medicament for the treatment of a cancer of the head and neck; a method of treating or preventing a cancer of the head and neck comprising administering a jointly therapeutically effective amount of such a combination to a subject in need thereof; and a commercial package thereof.
(FR)La présente invention concerne : une combinaison pharmaceutique comprenant (a) un composé inhibiteur de phosphatidylinositol-3-kinase (PI3K) de formule (I), telle que définie dans la description, ou un sel pharmaceutiquement acceptable de celui-ci, et (b) du paclitaxel, ou un sel pharmaceutique acceptable de celui-ci, pour une utilisation simultanée, séparée ou séquentielle, afin de traiter un cancer de la tête et du cou; une composition pharmaceutique comprenant ladite combinaison; l'utilisation de ladite combinaison pour préparer un médicament destiné à traiter un cancer de la tête et du cou; un procédé de traitement ou de prévention d'un cancer de la tête et du cou comprenant l'administration d'une quantité conjointement thérapeutiquement efficace d'une telle combinaison à un patient en ayant besoin; et un emballage commercial de celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)