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Machine translation
1. (WO2014181115) CGB2 AND CGB1 GENES; DIAGNOSIS, MONITORING AND TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/181115    International Application No.:    PCT/GB2014/051412
Publication Date: 13.11.2014 International Filing Date: 08.05.2014
IPC:
C12Q 1/68 (2006.01)
Applicants: MAP IP HOLDING LIMITED [GB/GB]; 28 Morley Drive Ely, CB6 3FQ (GB)
Inventors: ILES, Ray Kruse; (GB).
BUTLER, Stephen Andrew; (GB)
Agent: HART, Deborah Mary; Kilburn & Strode LLP 20 Red Lion Street London Greater London WC1R 4PJ (GB)
Priority Data:
1308259.9 08.05.2013 GB
Title (EN) CGB2 AND CGB1 GENES; DIAGNOSIS, MONITORING AND TREATMENT OF CANCER
(FR) GÈNES CGB2 ET CGB1; DIAGNOSTIC, SUIVI ET TRAITEMENT DE CANCER
Abstract: front page image
(EN)The present invention relates to methods for screening human tissue or fluid samples for changes in the expression of genes, in particular CGB2and CBG1, characteristic of poor prognosis in cancer such as bladder cancer. The methods have application for the screening, diagnosis or monitoring of other common epithelial cancers including those of the bladder, breast, cervix, colon, endometrium, kidney, lung (including small cell lung carcinoma - SCLC), nasal/pharynx, oro/facial, ovary, prostate, pancreas, vagina and vulva. Methods of treating cancers by reducing the level of expression of CGB2and CGB1or products thereof are also disclosed.
(FR)La présente invention concerne des procédés pour balayer des échantillons de tissu ou de fluide humain en vue de changements de l'expression de gènes, en particulier CGB2 et CGB1, caractéristiques d'un mauvais pronostic de cancer, tel qu'un cancer de la vessie. L'invention concerne des procédés, qui sont appliqués pour le balayage, le diagnostic ou le suivi d'autres cancers épithéliaux communs, y compris ceux de la vessie, du sein, du col de l'utérus, du côlon, de l'endomètre, du rein, du poumon (comprenant un carcinome pulmonaire à petites cellules, SCLC), nasal/pharynx, oro/facial, des ovaires, de la prostate, du pancréas, du vagin et de la vulve. L'invention concerne également des procédés de traitement de cancers par réduction du niveau d'expression de CGB2 et CGB1 ou de leurs produits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)