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1. (WO2014179764) METHOD OF TREATING ATRIAL FIBRILLATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179764    International Application No.:    PCT/US2014/036689
Publication Date: 06.11.2014 International Filing Date: 02.05.2014
IPC:
A61K 31/495 (2006.01), A61K 31/55 (2006.01), A61P 9/06 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, California 94404 (US).
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US/US]; 330 Brookline Avenue Boston, Massachusetts 02215 (US)
Inventors: BELARDINELLI, Luiz; (US).
VERRIER, Richard; (US).
ZENG, Dewan; (US)
Agent: TANNER, Lorna L.; Sheppard Mullin Richter & Hampton LLP 379 Lytton Avenue Palo Alto, California 94301-1479 (US)
Priority Data:
61/819,477 03.05.2013 US
Title (EN) METHOD OF TREATING ATRIAL FIBRILLATION
(FR) MÉTHODE DE TRAITEMENT DE LA FIBRILLATION AURICULAIRE
Abstract: front page image
(EN)The present disclosure relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a therapeutically effective amount of ivabradine or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of ranolazine. Also provided are methods for modulating ventricular and atrial rate. This disclosure also relates to pharmaceutical formulations that are suitable for such combined administration.
(FR)La présente invention concerne une méthode de traitement ou de prévention de la fibrillation auriculaire et/ou du flutter auriculaire, qui consiste à administrer conjointement une quantité thérapeutiquement efficace d'ivabradine ou un de ses sels pharmaceutiquement acceptables et une quantité thérapeutiquement efficace de ranolazine. L'invention concerne également des méthodes de modulation des rythmes ventriculaire et auriculaire. L'invention concerne aussi des formulations pharmaceutiques qui sont adaptées à ce type d'administration combinée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)