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1. (WO2014179760) CYCLIC DI-NUCLEOTIDE INDUCTION OF TYPE I INTERFERON
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179760    International Application No.:    PCT/US2014/036685
Publication Date: 06.11.2014 International Filing Date: 02.05.2014
IPC:
C07H 19/00 (2006.01), C07K 14/555 (2006.01), C12P 21/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 12th Floor Oakland, California 94607 (US)
Inventors: VANCE, Russell E.; (US).
HAMMOND, Ming C.; (US).
BURDETTE, Dara; (US).
DINER, Elie J.; (US).
WILSON, Stephen C.; (US)
Agent: FIELD, Bret E.; BOZICEVIC, FIELD & FRANCIS LLP 1900 University Avenue, Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/819,499 03.05.2013 US
Title (EN) CYCLIC DI-NUCLEOTIDE INDUCTION OF TYPE I INTERFERON
(FR) INDUCTION DE DINUCLÉOTIDE CYCLIQUE DE L'INTERFÉRON DE TYPE I
Abstract: front page image
(EN)Methods and compositions are provided for increasing the production of a type I interferon (IFN) in a cell. Aspects of the methods include increasing the level of a 2'-5' phosphodiester linkage comprising cyclic-di-nucleotide in a cell in a manner sufficient to increase production of the type I interferon (IFN) by the cell. Also provided are compositions and kits for practicing the embodiments of the methods.
(FR)L'invention concerne des procédés et des compositions qui permettent d'augmenter la production d'un interféron de type I (IFN) dans une cellule. Certains aspects des procédés comprennent l'augmentation du taux d'une liaison 2'-5' phosphodiester comportant un dinucléotide cyclique dans une cellule d'une manière suffisante pour augmenter la production de l'interféron de type I (IFN) par la cellule. L'invention concerne également des compositions et des nécessaires pour la mise en œuvre des modes de réalisation des procédés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)