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1. (WO2014179627) COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179627    International Application No.:    PCT/US2014/036463
Publication Date: 06.11.2014 International Filing Date: 01.05.2014
IPC:
C12N 15/113 (2010.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 2855 Gazelle Court Carlsbad, CA 92010 (US)
Inventors: PRAKASH, Thazha, P.; (US).
SETH, Punit, P.; (US).
SWAYZE, Eric, E.; (US)
Agent: TUNG, Jeffrey, J.; Isis Pharmaceuticals, Inc. 2855 Gazelle Court Carlsbad, CA 92010 (US)
Priority Data:
61/843,887 08.07.2013 US
61/823,826 15.05.2013 US
61/818,442 01.05.2013 US
61/986,867 30.04.2014 US
61/976,991 08.04.2014 US
61/880,790 20.09.2013 US
61/871,673 29.08.2013 US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION
(FR) COMPOSITIONS ET MÉTHODES POUR MODULER L'EXPRESSION DE HBV ET DE TTR
Abstract: front page image
(EN)Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. In certain embodiments, the present disclosure provides conjugated antisense compounds. In certain embodiments, the present disclosure provides conjugated antisense compounds comprising an antisense oligonucleotide complementary to a nucleic acid transcript of transthyretin (TTR).
(FR)L'invention concerne des composés oligomères à groupes conjugués. Dans certains modes de réalisation de l'invention, ces composés oligomères sont conjugués à la N-acétylgalactosamine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)