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1. (WO2014179625) COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179625    International Application No.:    PCT/US2014/036460
Publication Date: 06.11.2014 International Filing Date: 01.05.2014
IPC:
C07K 14/775 (2006.01), C12N 15/113 (2010.01), A61K 48/00 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 2855 Gazelle Court Carlsbad, CA 92010 (US)
Inventors: PRAKASH, Thazha, P.; (US).
SETH, Punit, P.; (US).
SWAYZE, Eric, E.; (US).
GRAHAM, Mark, J.; (US)
Agent: LIANG, Teresa, Y.; (US)
Priority Data:
61/823,826 15.05.2013 US
61/843,887 08.07.2013 US
61/818,442 01.05.2013 US
61/880,790 20.09.2013 US
61/976,991 08.04.2014 US
61/986,867 30.04.2014 US
61/871,673 29.08.2013 US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION
(FR) COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'EXPRESSION DE L'APOLIPOPROTÉINE (A)
Abstract: front page image
(EN)Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
(FR)L'invention concerne des composés oligomères avec des groupes conjugués ciblant l'apolipoprotéine (a) [apo(a)]. Dans certains modes de réalisation, les composés oligomères ciblant l'apo(a) sont conjugués à N-acétylgalactosamine. L'invention concerne également des composés oligomères conjugués ciblant l'apo(a) utilisés pour réduire l'apo(a) et traiter, prévenir ou améliorer les maladies, les affections ou pathologies associées à l'apo(a) et/ou la Lp(a). Les maladies, affections ou pathologies inflammatoires, cardiovasculaires et/ou métaboliques figurent parmi les maladies, affections ou pathologies associées à l'apo(a) et/ou la Lp(a). Les composés oligomères conjugués décrits ici peuvent être utilisés pour traiter ces maladies, affections ou pathologies chez un patient ayant besoin d'un tel traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)