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1. (WO2014179498) SERINE/THREONINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179498    International Application No.:    PCT/US2014/036249
Publication Date: 06.11.2014 International Filing Date: 30.04.2014
IPC:
C07D 471/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, CA 94080-4990 (US)
Inventors: CRAWFORD, James, J.; (US).
LEE, Wendy; (US).
RUDOLPH, Joachim; (US)
Agent: MCELHONE, Katharine, E.; Morrison & Foerster LLP 755 Page Mill Road Palo Alto, CA 94304-1018 (US)
Priority Data:
61/817,530 30.04.2013 US
Title (EN) SERINE/THREONINE KINASE INHIBITORS
(FR) INHIBITEURS DE LA SÉRINE/THRÉONINE KINASE
Abstract: front page image
(EN)Compounds having the formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, X1, X2, and Ar are as defined herein, are inhibitors of PAKl. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders using such compounds.
(FR)L'invention concerne des composés inhibiteurs de PAK1 ayant la formule I ou l'un de leurs sels pharmaceutiquement acceptables, où R1, R2, X1, X2, et Ar sont tels que définis dans la description. L'invention concerne aussi des compositions et des méthodes pour traiter le cancer et les troubles hyperprolifératifs au moyen de ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)