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1. (WO2014179494) SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179494    International Application No.:    PCT/US2014/036243
Publication Date: 06.11.2014 International Filing Date: 30.04.2014
IPC:
A61K 39/395 (2006.01), A61K 39/00 (2006.01), C12P 21/08 (2006.01)
Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION [US/US]; P.O. Box 483 Fort Collins, Colorado 80522 (US)
Inventors: COHEN, Robert E.; (US).
CHOI, Yun-Seok; (US)
Agent: LAHERTY, Carol D.; Cooley LLP 1299 Pennsylvania Avenue, NW Suite 700 Washington, District of Columbia 20004 (US)
Priority Data:
61/817,517 30.04.2013 US
Title (EN) SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS
(FR) DÉTECTEURS ET DOSAGES DE PROTÉINES D'UBIQUITINE OU D'UBIQUITINE-LIKE
Abstract: front page image
(EN)The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or toal ubiquitin or free or total ubiquitin-like proteins in various types of samples.
(FR)Cette invention concerne des compositions comprenant des polypeptides chimériques qui se lient à des protéines d'ubiquitine libres ou à des protéines d'ubiquitine-like libres à une haute affinité, ainsi que des polypeptides chimériques qui se lient à la fois à des protéines d'ubiquitine libres et conjuguées ou à des protéines d'ubiquitine-like libres et conjuguées, et des procédés d'utilisation desdits polypeptides chimériques pour déterminer la quantité de protéines d'ubiquitine libre ou totale ou de protéines d'ubiquitine-like libre ou totale dans divers types d'échantillons.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)