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1. (WO2014179476) TRUNCATED CONSTRUCTS OF RIPK3 AND RELATED USES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179476    International Application No.:    PCT/US2014/036196
Publication Date: 06.11.2014 International Filing Date: 30.04.2014
IPC:
A61K 38/17 (2006.01), A61P 35/00 (2006.01), C07K 14/47 (2006.01)
Applicants: ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 262 Danny Thomas Place, Mail Stop 742 Memphis, TN 38105 (US)
Inventors: GREEN, Douglas; (US).
OBERST, Andrew; (US)
Agent: CARROLL, Peter, G.; (US)
Priority Data:
61/818,233 01.05.2013 US
Title (EN) TRUNCATED CONSTRUCTS OF RIPK3 AND RELATED USES
(FR) CONSTRUCTIONS TRONQUÉES DE RIPK3 ET UTILISATIONS CONNEXES
Abstract: front page image
(EN)The invention provides methods and compositions for inducing necroptosis in target cells, including for example cancer cells. This invention provides compositions and methods for the controlled expression and formation of full length RDPK3 homodimers, truncated RTPK3 oligomers and/or full length RIPK3/RIPK1 heterodimers in target cells both in vitro and in vivo therapeutic and research applications.
(FR)Cette invention concerne des méthodes et des compositions destinées à induire la nécroptose dans des cellules cibles, comprenant par exemple des cellules cancéreuses. Des compositions et des méthodes pour l'expression et la formation contrôlées d'homodimères RDPK3 pleine longueur, d'oligomères RTPK3 tronqués et/ou d'hétérodimères RIPK3/RIPK1 pleine longueur dans des cellules cibles à des fins thérapeutiques et de recherche à la fois in vitro et in vivo sont en outre décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)