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Machine translation
1. (WO2014179226) SUBSTITUTED 1-BENZYLQUINOXALIN-2 (1H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179226    International Application No.:    PCT/US2014/035700
Publication Date: 06.11.2014 International Filing Date: 28.04.2014
IPC:
A01N 43/58 (2006.01), A61K 31/50 (2006.01), A61K 31/495 (2006.01)
Applicants: VANDERBILT UNIVERSITY [US/US]; 305 Kirkland Hall 2201 West End Avenue Nashville, TN 37240 (US)
Inventors: LINDSLEY, Craig, W.; (US).
CONN, P., Jeffrey; (US).
STAUFFER, Shaun, R.; (US).
PANARESE, Joseph, David; (US)
Agent: HARTWIG, Gregory J.; (US)
Priority Data:
61/816,797 28.04.2013 US
Title (EN) SUBSTITUTED 1-BENZYLQUINOXALIN-2 (1H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M1
(FR) ANALOGUES DE 1-BENZYLQUINOXALIN-2 (1H)-ONE SUBSTITUÉS UTILISÉS COMME MODULATEURS ALLOSTÉRIQUES POSITIFS DU RÉCEPTEUR MUSCARINIQUE DE L'ACÉTYLCHOLINE M1
Abstract: front page image
(EN)The invention relates to substituted 1-benzylquinoxalin-2(1 H)-one analogs, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); methods for making the compounds; pharmaceutical compositions; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction.
(FR)L'invention concerne des analogues de 1-benzylquinoxalin-2(1H)-one substitués qui s'utilisent comme modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine M1 (mAChR M1). La présente invention concerne également des procédés pour produire des composés et des compositions pharmaceutiques ainsi que des méthodes de traitement de troubles neurologiques et psychiatriques associés à un dysfonctionnement des récepteurs muscariniques de l'acétylcholine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)