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1. (WO2014179202) METHODS FOR DIAGNOSIS OF CELIAC DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179202    International Application No.:    PCT/US2014/035643
Publication Date: 06.11.2014 International Filing Date: 28.04.2014
IPC:
A61B 8/00 (2006.01), A61K 31/395 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Office Of Technology Licensing 1705 El Camino Real Palo Alto, CA 94306 (US).
DAVIS, Mark, M. [US/US]; (US).
HAN, Arnold [US/US]; (US).
NEWELL, Evan, W. [US/SG]; (SG)
Inventors: DAVIS, Mark, M.; (US).
HAN, Arnold; (US).
NEWELL, Evan, W.; (SG)
Agent: BUCHBINDER, Jenny; 29 Clinton Street #201 Redwood City, CA 94062 (US)
Priority Data:
61/818,538 02.05.2013 US
Title (EN) METHODS FOR DIAGNOSIS OF CELIAC DISEASE
(FR) PROCÉDÉS DE DIAGNOSTIC DE LA MALADIE CŒLIAQUE
Abstract: front page image
(EN)A diagnostic test for celiac disease is disclosed. In particular, the invention relates to a method of diagnosing celiac disease by detecting activated, gut-bound CD8+ alpha-beta T lymphocytes and gamma-delta T lymphocytes in the peripheral blood of a subject who has consumed gluten for one to three days. This diagnostic test has a number of advantages over current tests for celiac test, including that the test is noninvasive, relatively inexpensive, and requires voluntary gluten ingestion over a short period of time.
(FR)La présente invention se rapporte à un test de diagnostic de la maladie cœliaque. En particulier, l'invention se rapporte à un procédé permettant de diagnostiquer la maladie cœliaque par détection des lymphocytes T alpha-bêta CD8+ activés de la muqueuse intestinale et des lymphocytes T gamma-delta présents dans le sang périphérique d'un sujet qui a consommé du gluten pendant une période allant de un à trois jours. Ce test de diagnostic présente un certain nombre d'avantages par rapport aux tests classiques pour dépister la maladie cœliaque. Entre autres, le test est non invasif, relativement bon marché, et requiert une ingestion de gluten volontaire pendant une période de temps courte.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)