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1. (WO2014179186) ALDOSTERONE SYNTHASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179186    International Application No.:    PCT/US2014/035596
Publication Date: 06.11.2014 International Filing Date: 28.04.2014
IPC:
C07D 471/04 (2006.01), A61K 31/444 (2006.01), C07D 498/04 (2006.01), A61P 9/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173 55216 Ingelheim am Rhein (DE) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BALESTRA, Michael [US/US]; (US) (US only).
BURKE, Jennifer [US/US]; (US) (US only).
CHEN, Zhidong [CN/US]; (US) (US only).
COGAN, Derek [US/US]; (US) (US only).
FADER, Lee [CA/US]; (US) (US only).
GUO, Xin [CN/US]; (US) (US only).
MCKIBBEN, Bryan [US/US]; (US) (US only).
MARSHALL, Daniel Richard [US/US]; (US) (US only).
NEMOTO, Peter Allen [US/US]; (US) (US only).
YU, Hui [CN/US]; (US) (US only)
Inventors: BALESTRA, Michael; (US).
BURKE, Jennifer; (US).
CHEN, Zhidong; (US).
COGAN, Derek; (US).
FADER, Lee; (US).
GUO, Xin; (US).
MCKIBBEN, Bryan; (US).
MARSHALL, Daniel Richard; (US).
NEMOTO, Peter Allen; (US).
YU, Hui; (US)
Agent: MORRIS, Michael P.; Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road P.O. Box 368 Ridgefield, CT 06877-0368 (US)
Priority Data:
61/817,564 30.04.2013 US
61/912,571 06.12.2013 US
Title (EN) ALDOSTERONE SYNTHASE INHIBITORS
(FR) INHIBITEURS DE L'ALDOSTÉRONE SYNTHASE
Abstract: front page image
(EN)The present invention relates to compounds of formula (I): I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, mand nare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of a variety of diseases that are mediated or sustained by aldosterone activity, including renal disease, diabetic nephropathy, cardiovascular diseases and fibrotic disorders, processes for preparing these compounds and intermediates useful in these processes.
(FR)La présente invention concerne des composés de formule (I) : I et leurs sels pharmaceutiquement acceptables, R1, R2, R3, R4, R5, R6, R7, W, Y, met nétant tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes d'utilisation de ces composés pour traiter diverses maladies médiées ou favorisées par l'activité de l'aldostérone, notamment une maladie rénale, une néphropathie diabétique, les maladies cardiovasculaires et les troubles fibrotiques, des procédés de préparation ces composés et des intermédiaires utiles dans ces procédés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)