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Machine translation
1. (WO2014179154) NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/179154    International Application No.:    PCT/US2014/035384
Publication Date: 06.11.2014 International Filing Date: 25.04.2014
IPC:
A61K 31/655 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
LIM, Jongwon [KR/US]; (US) (US only).
HUANG, Xianhai [CN/US]; (US) (US only).
FERGUSON, Ronald, D. [US/US]; (US) (US only).
ZHOU, Wei [US/US]; (US) (US only).
BOYCE, Christopher, W. [US/US]; (US) (US only).
SILIPHAIVANH, Phieng [US/US]; (US) (US only).
WITTER, David, J. [US/US]; (US) (US only).
MALETIC, Milana, M. [US/US]; (US) (US only).
KOZLOWSKI, Joseph, A. [US/US]; (US) (US only).
WILSON, Kevin, J. [GB/US]; (US) (US only)
Inventors: LIM, Jongwon; (US).
HUANG, Xianhai; (US).
FERGUSON, Ronald, D.; (US).
ZHOU, Wei; (US).
BOYCE, Christopher, W.; (US).
SILIPHAIVANH, Phieng; (US).
WITTER, David, J.; (US).
MALETIC, Milana, M.; (US).
KOZLOWSKI, Joseph, A.; (US).
WILSON, Kevin, J.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
61/817,571 30.04.2013 US
Title (EN) NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
(FR) NOUVEAUX COMPOSÉS QUI SONT DES INHIBITEURS D'ERK
Abstract: front page image
(EN)Disclosed are the ERK inhibitors of formula (I) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I). This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier. This invention also provides a method of inhibiting ERK (i.e., inhibiting the activity of ERK2) in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of formula (I).
(FR)L'invention concerne des inhibiteurs d'ERK de formule (1) : et les sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des méthodes de traitement du cancer à l'aide des composés de formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)