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1. (WO2014178954) PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/178954    International Application No.:    PCT/US2014/029583
Publication Date: 06.11.2014 International Filing Date: 14.03.2014
IPC:
C07D 231/12 (2006.01), A61K 31/415 (2006.01), A61K 31/4155 (2006.01), C07D 401/06 (2006.01), C07D 405/04 (2006.01), C07D 405/06 (2006.01), C07D 405/12 (2006.01), C07D 413/04 (2006.01), A61P 35/00 (2006.01), A61P 25/00 (2006.01), A61P 37/00 (2006.01), A61P 3/00 (2006.01), A61P 9/00 (2006.01)
Applicants: EPIZYME, INC. [US/US]; 400 Technology Square 4th Floor Cambridge, MA 02139 (US)
Inventors: CHESWORTH, Richard; (US).
MITCHELL, Lorna, Helen; (US).
SHAPIRO, Gideon; (US).
BORIACK-SJODIN, Paula, Ann; (US).
MORADEL, Oscar, Miguel; (US).
JIN, Lei; (US).
DUNCAN, Kenneth, W.; (US)
Agent: WEATHERHEAD, Robin, A.; Wof, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/781,054 14.03.2013 US
Title (EN) PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DE L'ARGININE MÉTHYLTRANSFÉRASE ET UTILISATIONS DE CEUX-CI
Abstract: front page image
(EN)Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.Formula (I).
(FR)La présente invention concerne des composés de Formule (I), leurs sels pharmaceutiquement acceptables, et des compositions pharmaceutiques de ceux-ci. Les composés décrits ici sont utiles pour inhiber l'activité de l'arginine méthyltransférase. Des procédés d'utilisation des composés pour le traitement de troubles médiés par l'arginine méthyltransférase sont également décrits. Formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)