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1. (WO2014177982) ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/177982    International Application No.:    PCT/IB2014/061012
Publication Date: 06.11.2014 International Filing Date: 25.04.2014
IPC:
C07D 405/14 (2006.01), C07D 413/14 (2006.01), C07D 401/12 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), A61K 31/381 (2006.01), A61K 31/4427 (2006.01), A61P 35/00 (2006.01)
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB/GB]; 980 Great West Road Brentford Middlesex TW89GS (GB)
Inventors: BLACKLEDGE, JR., Charles William; (US).
BURGESS, Joelle Lorraine; (US).
JOHNSON, Neil W.; (US).
KASPAREC, Jiri; (US).
KNIGHT, Steven David; (US).
LAFRANCE III, Louis V.; (US).
LUENGO, Juan I.; (US).
MILLER, William Henry; (US).
NEWLANDER, Kenneth Allen; (US).
ROMERIL, Stuart Paul; (US).
SCHULZ, Mark; (US).
SU, Dai-Shi; (US).
TIAN, Xinrong; (US)
Priority Data:
61/817,436 30.04.2013 US
61/842,038 02.07.2013 US
61/907,024 21.11.2013 US
61/936,460 06.02.2014 US
Title (EN) ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS
(FR) ACTIVATEUR D'INHIBITEURS DE L'HOMOLOGUE 2 DE ZESTE
Abstract: front page image
(EN)This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.
(FR)La présente invention concerne de nouveaux composés de formule (I) qui sont des inhibiteurs de l'activateur de l'homologue 2 de Zeste (EZH2), des compositions pharmaceutiques les contenant, des procédés pour leur préparation, et leur utilisation en thérapie pour le traitement de cancers. (I)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)