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1. (WO2014177060) BIHETEROARYL COMPOUNDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/177060    International Application No.:    PCT/CN2014/076654
Publication Date: 06.11.2014 International Filing Date: 30.04.2014
IPC:
C07D 401/14 (2006.01), C07D 403/14 (2006.01), A61K 31/444 (2006.01), A61K 31/506 (2006.01), A61P 25/00 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/28 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco California 94080 (US) (US only)
Inventors: CHEN, Kevin X.; (CN).
DONG, Liting; (CN).
ESTRADA, Anthony; (US).
GIBBONS, Paul; (US).
HUESTIS, Malcolm; (US).
KELLAR, Terry; (US).
LIU, Wen; (US).
LYSSIKATOS, Joseph P.; (US).
MA, Changyou; (CN).
OLIVERO, Alan; (US).
PATEL, Snahel; (US).
SHORE, Daniel; (US).
SIU, Michael; (US)
Agent: ZHONGZI LAW OFFICE; 7F, New Era Building, 26 Pinganli Xidajie Xicheng District Beijing 100034 (CN)
Priority Data:
61/817,966 01.05.2013 US
Title (EN) BIHETEROARYL COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS BIHÉTÉROARYLE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R 1, R 2, R 3, X 1, X 2, A and Cy variable in Formula (I-I) all have the meaning as defined herein.
(FR)La présente invention concerne des composés représentés par la formule I-I ainsi que des modes de réalisation et des sels correspondants qui sont destinés au traitement de maladies (notamment, de maladies neurodégénératives). R 1, R 2, R 3, X 1, X 2, A et la variable Cy de la formule I-I possèdent tous la signification telle que définie dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)