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1. (WO2014177042) NOVEL LINKER AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/177042    International Application No.:    PCT/CN2014/076414
Publication Date: 06.11.2014 International Filing Date: 28.04.2014
IPC:
C07K 2/00 (2006.01), C07K 4/00 (2006.01), C07K 1/04 (2006.01), A61K 47/48 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), A61P 37/02 (2006.01), A61P 31/00 (2006.01), A61P 25/00 (2006.01), A61P 9/00 (2006.01)
Applicants: QIN, Gang [CN/CN]; (CN)
Inventors: QIN, Gang; (CN).
YUAN, Jinduo; (CN).
TAN, Chubing; (CN).
JIANG, Lu; (CN)
Agent: SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD.; Room 503, Floor 5, Tower A No.21, A, Haidian South Road Zhongguancun Intellectual Property Building, Haidian District Beijing 100080 (CN)
Priority Data:
201310171802.4 28.04.2013 CN
201410111810.4 11.03.2014 CN
Title (EN) NOVEL LINKER AND PREPARATION METHOD THEREOF
(FR) NOUVEAU LIEUR ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 一种新型的连接子及其制备方法和用途
Abstract: front page image
(EN)Provided in the present invention is a linker and a preparation method thereof, wherein one end of the linker may covalently link a small molecule compound and the like and the other end may specifically and covalently link a targeting substance site under the action of Sortase enzyme. The linker of the present invention can be used to prepare a targeting drug conjugate.
(FR)La présente invention concerne un lieur et un procédé de préparation de associé, une extrémité du lieur pouvant être liée de façon covalente à un composé à petite molécule et similaire et l'autre extrémité pouvant se lier spécifiquement et de façon covalente à un site de substance de ciblage sous l'action d'une enzyme Sortase. Le lieur de la présente invention peut être utilisé pour préparer un conjugué substance de ciblage-médicament.
(ZH)本发明提供了一种连接子及其制备方法,其一端可与小分子化合物等共价连接,另一端可在Sortase酶作用下与靶向性物质位点特异地共价连接。本发明的连接子可用于制备靶向性药物偶联物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)