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1. (WO2014177038) AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/177038    International Application No.:    PCT/CN2014/076377
Publication Date: 06.11.2014 International Filing Date: 28.04.2014
IPC:
C07D 491/056 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/517 (2006.01), A61K 31/553 (2006.01), A61K 31/5415 (2006.01), A61P 35/00 (2006.01), A61P 9/10 (2006.01), A61P 11/00 (2006.01), A61P 27/02 (2006.01), A61P 3/10 (2006.01)
Applicants: SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; Northern Industrial Area, Songshan Lake Dongguan, Guangdong 523000 (CN)
Inventors: ZHANG, Yingjun; (CN).
LIU, Bing; (CN).
LIU, Jinlei; (CN).
ZHANG, Jiancun; (CN).
CHENG, Changchung; (CN)
Agent: TSINGYIHUA INTELLECTUAL PROPERTY LLC; Room 301, Trade Building, Zhaolanyuan, Tsinghua University, Qinghuayuan, Haidian District Beijing 100084 (CN)
Priority Data:
201310156470.2 28.04.2013 CN
201410108773.1 23.03.2014 CN
Title (EN) AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE THEREOF
(FR) DÉRIVÉS D'AMINOQUINAZOLINE, LEURS SELS ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Provided herein are aminoquinazoline compounds, salts and uses thereof. The compounds have Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Also provided herein are pharmaceutical compositions containing the compounds disclosed herein, and uses of the compounds or the compositions for preventing, managing, treating or lessening the severity of a proliferative disorder in a patient and for modulating the protein tyrosine kinase activity.
(FR)La présente invention concerne des composés aminoquinazoline, leurs sels et leurs utilisations. Les composés sont représentés par la formule (I), ou un stéréoisomère, un isomère géométrique, un tautomère, un N-oxyde, un hydrate, un solvate, un métabolite, un sel pharmaceutiquement acceptable ou un promédicament correspondant. La présente invention concerne également des compositions pharmaceutiques contenant les composés tels que définis dans la description, et les utilisations des composés ou des compositions aux fins de prévention, de prise en charge, de traitement ou d'atténuation de la gravité d'un trouble de prolifération chez un patient et aux fins de modulation de l'activité protéine tyrosine kinase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)