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1. WO2014176591 - REACTION-BASED FLUORESCENT PROBES FOR DETECTING ZINC

Publication Number WO/2014/176591
Publication Date 30.10.2014
International Application No. PCT/US2014/035673
International Filing Date 28.04.2014
IPC
G01N 33/20 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
20Metals
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
CPC
A61B 5/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0071by measuring fluorescence emission
A61B 5/14546
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
14546for measuring analytes not otherwise provided for, e.g. ions, cytochromes
A61B 5/1455
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
A61B 5/4041
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4029for evaluating the peripheral nervous systems
4041Evaluating nerves condition
A61B 5/4064
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4058for evaluating the central nervous system
4064Evaluating the brain
A61B 5/425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
4222Evaluating particular parts, e.g. particular organs
425pancreas
Applicants
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US]
Inventors
  • RADFORD, Robert J.
  • LIPPARD, Stephen J.
  • CHYAN, Wen
Agents
  • GORDON, Dana M.
Priority Data
61/816,29126.04.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REACTION-BASED FLUORESCENT PROBES FOR DETECTING ZINC
(FR) SONDES FLUORESCENTES BASÉES SUR UNE RÉACTION POUR DÉTECTER DU ZINC
Abstract
(EN)
Disclosed are compounds and methods useful in the detection of, e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+. Importantly, the compounds do not exhibit substantial fluorescence in the absence of zinc.
(FR)
L'invention concerne des composés et des procédés utiles pour la détection de Zn2+ par exemple, in vitro et in vivo. Ces composés incluent des acides aminés et des peptides fonctionnalisés à l'aide d'une fraction qui se lie, par exemple, à Zn2+. Il est important de noter que ces composés ne présentent pas de fluorescence sensible en l'absence de zinc.
Also published as
Latest bibliographic data on file with the International Bureau