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1. WO2014174338 - PROCESS FOR PREPARING AN INTERMEDIATE USEFUL IN THE PRODUCTION OF DROSPIRENONE

Publication Number WO/2014/174338
Publication Date 30.10.2014
International Application No. PCT/IB2013/053158
International Filing Date 22.04.2013
IPC
C07J 75/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
75Processes for the preparation of steroids, in general
CPC
C07J 53/008
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
53Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, ; including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
002Carbocyclic rings fused
0043 membered carbocyclic rings
008in position 15/16
Applicants
  • INDUSTRIALE CHIMICA S.R.L. [IT]/[IT]
Inventors
  • LENNA, Roberto
  • BARBIERI, Francesco
  • LUONI, Maria, Giovanna
  • NOSEDA, Monica
Agents
  • PALLADINO, Saverio, Massimo
Priority Data
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) PROCESS FOR PREPARING AN INTERMEDIATE USEFUL IN THE PRODUCTION OF DROSPIRENONE
(FR) PROCÉDÉ DE PRÉPARATION D'UN INTERMÉDIAIRE UTILE POUR PRODUIRE LA DROSPIRÉNONE
Abstract
(EN)
A process is described wherein, using 17α-(3-hydroxyprapyl)-6β,7β,15β,16β- dimethylene-5β-androstane-3β,5,17β-triol (III) as starting product, there is obtained 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-17α-pregna-21, 17-carbolactone (I), a useful intermediate in the synthesis of the compound drospirenone, having contraceptive action: (Formula III & I) (III) (I)
(FR)
L'invention concerne un procédé permettant d'obtenir, à partir du 17α-(3-hydroxyprapyl)-6β,7β,15β,16β- diméthylène-5β-androstane-3β,5,17β-triol (III) employé comme produit de départ, de la 3β,5-dihydroxy-6β,7β,15β,16β-diméthylène-5β-17α-pregna-21,17-carbolactone (I), un intermédiaire utile dans la synthèse de la drospirénone, un composé ayant une action contraceptive.
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