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1. WO2014171986 - STABLE COMPOSITIONS COMPRISING HEPARINOID, ACUTE-ACTING ANESTHETIC, AND BUFFER

Publication Number WO/2014/171986
Publication Date 23.10.2014
International Application No. PCT/US2014/013352
International Filing Date 28.01.2014
Chapter 2 Demand Filed 26.11.2014
IPC
A61K 31/727 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
727Heparin; Heparan
CPC
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/727
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
727Heparin; Heparan
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 9/0034
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
Applicants
  • URIGEN PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • PARSONS, C. Lowell
Agents
  • FARBER, Michael B.
Priority Data
61/757,59228.01.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABLE COMPOSITIONS COMPRISING HEPARINOID, ACUTE-ACTING ANESTHETIC, AND BUFFER
(FR) COMPOSITIONS STABLES COMPRENANT UN HÉPARINOÏDE, UN ANESTHÉSIQUE LOCAL ET UN TAMPON
Abstract
(EN)
Improved methods for preparing compositions including a heparinoid, an acute-acting anesthetic, and a buffer are described. These methods result in compositions in which the heparinoid and the acute-acting anesthetic are at least 90% stable for one year. Compositions prepared by these methods and having such improved stability properties are also described, as well as methods for use of these compositions for treating, ameliorating, or preventing lower urinary tract disorders such as interstitial cystitis.
(FR)
La présente invention se rapporte à des procédés perfectionnés permettant de préparer des compositions comprenant un héparinoïde, un anesthésique local et un tampon. Ces procédés donnent des compositions dans lesquelles l'héparinoïde et l'anesthésique local sont stables à au moins 90 % pendant un an. La présente invention se rapporte également à des compositions préparées par ces procédés et qui présentent de telles propriétés de stabilité améliorées, ainsi qu'à des procédés d'utilisation de ces compositions afin de traiter, d'améliorer ou d'empêcher des troubles du tractus urinaire inférieur tels que la cystite interstitielle.
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