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1. WO2014171546 - ORAL VACCINE HAVING IMPROVED CELLULAR IMMUNITY INDUCTION POTENCY

Publication Number WO/2014/171546
Publication Date 23.10.2014
International Application No. PCT/JP2014/061099
International Filing Date 18.04.2014
IPC
A61K 35/74 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
A61K 39/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
07Bacillus
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 2039/521
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
521inactivated (killed)
A61K 2039/523
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
523expressing foreign proteins
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/542
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
542oral/gastrointestinal
A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Applicants
  • アンジェスМG株式会社 ANGES MG, INC. [JP]/[JP]
  • バイオリーダーズ コーポレーション BIOLEADERS CORPORATION [KR]/[KR]
Inventors
  • 野村 栄司 NOMURA, Eiji
  • 天満 昭子 TEMMA, Akiko
  • 中澤 隆弘 NAKAZAWA, Takahiro
  • 森下 竜一 MORISHITA, Ryuichi
  • 李 日漢 LEE, II-Han
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2013-08880019.04.2013JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ORAL VACCINE HAVING IMPROVED CELLULAR IMMUNITY INDUCTION POTENCY
(FR) VACCIN ORAL AYANT UNE EFFICACITÉ D'INDUCTION D’IMMUNITÉ CELLULAIRE AMÉLIORÉE
(JA) 細胞性免疫誘導能が改善された経口ワクチン
Abstract
(EN)
Provided is an oral drug preparation for prevention or treatment of pathogenic infectious disease, containing a killed lactobacillus expressing an antigen of the pathogen on the surface, or a microgranular form thereof, having an average particle diameter of 2.68-30 μm. Also provided is an oral drug preparation for inducing cellular immunity to a target antigen, containing a killed lactobacillus expressing the target antigen on the surface, or a microgranular form thereof, having a particle diameter of 2.68-30 μm.
(FR)
L'invention concerne une préparation de médicament oral pour prévenir ou traiter une maladie infectieuse pathogène, contenant un lactobacille tué exprimant un antigène du pathogène sur la surface, ou une forme micro-granulaire de celui-ci, ayant un diamètre de particule moyen de 2,68-30 µm. L'invention concerne également une préparation de médicament oral pour induire une immunité cellulaire à un antigène cible, contenant un lactobacille tué exprimant l'antigène cible sur la surface, ou une forme micro-granulaire de celui-ci, ayant un diamètre de particule de 2,68-30 µm.
(JA)
 平均粒子径2.68~30μmの、病原体抗原を表面発現する死菌化乳酸菌又はその微粒化物を含む、当該病原体感染性疾患の予防又は治療のための経口製剤。粒子径2.68~30μmの、標的抗原を表面発現する死菌化乳酸菌又はその微粒化物を含む、当該標的抗原に対する細胞性免疫を誘導するための経口製剤。
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