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1. WO2014171528 - HETEROCYCLIC ACETIC ACID AMIDE COMPOUND

Publication Number WO/2014/171528
Publication Date 23.10.2014
International Application No. PCT/JP2014/061007
International Filing Date 18.04.2014
IPC
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/423 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 31/428 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
A61K 31/498 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
498Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
36Opioid-abuse
Applicants
  • アステラス製薬株式会社 ASTELLAS PHARMA INC. [JP]/[JP]
Inventors
  • 白木 良太 SHIRAKI, Ryota
  • 戸部 貴彦 TOBE, Takahiko
  • 川上 晋平 KAWAKAMI, Shimpei
  • 森友 博幸 MORITOMO, Hiroyuki
  • 大宮 誠 OHMIYA, Makoto
Agents
  • 森田 拓 MORITA, Hiroshi
Priority Data
2013-08715118.04.2013JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) HETEROCYCLIC ACETIC ACID AMIDE COMPOUND
(FR) COMPOSÉ D'AMIDE D'ACIDE ACÉTIQUE HÉTÉROCYCLIQUE
(JA) ヘテロ環酢酸アミド化合物
Abstract
(EN)
[Problem] To provide a compound of formula (I) that is useful as a dopamine D1 receptor positive allosteric modulator (D1 PAM). [Solution] The inventors studied a compound that has a dopamine D1 receptor positive allosteric modulating action and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating cognitive dysfunction, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug dependence, etc., have verified that a heterocyclic acetic acid amide compound has a dopamine D1 receptor positive allosteric modulating action, and have completed the present invention. This heterocyclic acetic acid amide compound has a dopamine D1 receptor positive allosteric modulating action and may be used as a preventive and/or therapeutic agent for cognitive dysfunction, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug dependence, etc.
(FR)
L'invention a pour but de proposer un composé de formule (I) qui est utile comme modulateur allostérique positif du récepteur de la dopamine D1 (D1 PAM). À cet effet, les inventeurs ont étudié un composé qui a une action de modulateur allostérique positif du récepteur de la dopamine D1 et est utile comme principe actif pour une composition pharmaceutique pour prévenir et/ou traiter un dysfonctionnement cognitif, les symptômes négatifs de la schizophrénie, la maladie de Parkinson, la maladie d'Alzheimer, la maladie de Huntington, la pharmacodépendance, etc., ont vérifié qu'un composé d'amide d'acide acétique hétérocyclique a une action de modulateur allostérique positif du récepteur de la dopamine D1, et ont terminé la présente invention. Ce composé d'amide d'acide acétique hétérocyclique a une action de modulateur allostérique positif du récepteur de la dopamine D1 et peut être utilisé comme agent de prévention et/ou thérapeutique pour un dysfonctionnement cognitif, les symptômes négatifs de la schizophrénie, la maladie de Parkinson, la maladie d'Alzheimer, la maladie de Huntington, la pharmacodépendance, etc.
(JA)
【課題】ドパミンD1 受容体ポジティブアロステリックモジュレーター(D1PAM)として有用な式(I)の化合物を提供する。 【解決手段】本発明者らは、ドパミンD1 受容体ポジティブアロステリックモジュレート作用を有し、認知機能障害、統合失調症陰性症状、パーキンソン病、アルツハイマー病、ハンチントン病、及び、薬物依存等の予防及び/又は治療用医薬組成物の有効成分として有用な化合物について検討し、ヘテロ環酢酸アミド化合物がドパミンD1 受容体ポジティブアロステリックモジュレート作用を有することを確認し、本発明を完成した。本発明のヘテロ環酢酸アミド化合物は、ドパミンD1 受容体ポジティブアロステリックモジュレート作用を有し、認知機能障害、統合失調症陰性症状、パーキンソン病、アルツハイマー病、ハンチントン病、及び、薬物依存等の予防及び/又は治療剤として使用しうる。
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