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1. (WO2014167112) A MUTANT SIALIDASE HAVING TRANS-SIALIDASE ACTIVITY FOR USE IN PRODUCTION OF SIALYLATED GLYCANS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/167112 International Application No.: PCT/EP2014/057422
Publication Date: 16.10.2014 International Filing Date: 11.04.2014
IPC:
C07K 14/435 (2006.01) ,C12N 9/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
Applicants: DANMARKS TEKNISKE UNIVERSITET[DK/DK]; Anker Engelundsvej 1 Bygning 101A, 2. sal DK-2800 Kgs. Lyngby, DK
Inventors: MIKKELSEN, Jørn Dalgaard; DK
JERS, Carsten; DK
MICHALAK, Malwina; DK
KEPP, Kasper Planeta; DK
LARSEN, Dorte Møller; DK
Agent: SIMPSON, Verena; Guardian IP Consulting I/S Diplomvej, Building 381 DK-2800 Kgs. Lyngby, DK
Priority Data:
13163551.812.04.2013EP
Title (EN) A MUTANT SIALIDASE HAVING TRANS-SIALIDASE ACTIVITY FOR USE IN PRODUCTION OF SIALYLATED GLYCANS
(FR) SIALIDASE MUTANTE AYANT UNE ACTIVITÉ DE TRANS-SIALIDASE DESTINÉE À ÊTRE UTILISÉE EN PRODUCTION DE GLYCANES SIALYLÉS
Abstract:
(EN) The invention provides a mutant enzyme having trans-sialidase activity (EC 3.2.1.18), characterized by an enhanced trans-sialidase:sialidase ratio when compared to its parent sialidase enzyme. Further the enzyme may be used in a method for trans-sialylating mono- and oligo-saccharides, including galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS), malto-oligosaccharides (MOS), isomalto-oligosaccarides (IMO), lactulose, melibiose, maltose, glycosyl sucrose, lactosucrose and fucose. Trans-sialidated mono- and oligo- saccharides, produced with the mutant enzyme, are useful in preparing infant formula, a prebiotic nutritional supplement, and a food supplement.
(FR) L'invention porte sur une enzyme mutante ayant une activité de trans-sialidase (EC 3.2.1.18), caractérisée par un rapport trans-sialidase:sialidase accru par comparaison avec son enzyme sialidase parente. En outre l'enzyme peut être utilisée dans un procédé pour la trans-sialylation de monosaccharides et d'oligosaccharides, notamment de galacto-oligosaccharides (GOS), de fructo-oligosaccharides (FOS), de malto-oligosaccharides (MOS), d'isomalto-oligosaccarides (IMO), de lactulose, de mélibiose, de maltose, de glycosylsaccharose, de lactosaccharose et de fucose. Les monosaccharides et oligosaccharides trans-sialylés produits à l'aide de l'enzyme mutante sont utiles en préparation de préparation pour nourrisson, de supplément nutritif prébiotique et de complément alimentaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)