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1. WO2014165633 - CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE

Publication Number WO/2014/165633
Publication Date 09.10.2014
International Application No. PCT/US2014/032742
International Filing Date 03.04.2014
IPC
C07C 49/597 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
587Unsaturated compounds containing a keto group being part of a ring
597of a five-membered ring
CPC
C07C 2601/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
10the ring being unsaturated
C07C 2602/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2602Systems containing two condensed rings
02the rings having only two atoms in common
04One of the condensed rings being a six-membered aromatic ring
10the other ring being six-membered, e.g. tetraline
C07C 311/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
20having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US]
Inventors
  • BALLATORE, Carlo
  • BRUNDEN, Kurt, R.
  • LEE, Virginia, M.Y.
  • SMITH, Amos, B., III.
  • TROJANOWSKI, John, Q.
  • WANG, Xiaozhao
Agents
  • CALDWELL, John, W.
Priority Data
61/808,26004.04.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE
(FR) DÉRIVÉS DE CYCLOALKYLE-DIONE ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6alkyl, C1-6alkaryl, aryl, or heteroaryl; and X is O or NH. Tautomers, enantiomers, and diastereomers, as well as pharmaceutically acceptable salt forms, of compounds of formula I are also within the scope of the invention. Methods of preparing and using the compounds of formula I are also described.
(FR)
La présente invention concerne des composés de formule I : dans laquelle A représente n qui est égal à 0, 1 ou 2; m est égal à 0 ou 1; R1 représente H ou un groupe alkyle en C1 à C6 et R2 représente H, un groupe alkyle en C1 à C6, un groupe aryle, hétéroaryle ou alkaryle en C1 à C6; et X représente O ou NH. L'invention concerne également des tautomères, des énantiomères et des diastéréoisomères, ainsi que des formes de type sels pharmaceutiquement acceptables des composés de formule I. L'invention concerne, en outre, des procédés de préparation et d'utilisation des composés de formule I.
Also published as
Latest bibliographic data on file with the International Bureau