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1. WO2014165131 - METHODS AND MATERIALS FOR HEMATOENDOTHELIAL DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED CONDITIONS

Publication Number WO/2014/165131
Publication Date 09.10.2014
International Application No. PCT/US2014/024518
International Filing Date 12.03.2014
IPC
C12N 5/0789 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0789Stem cells; Multipotent progenitor cells
C12N 5/0775 2010.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
C12N 5/071 2010.01
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5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
C12N 5/00 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C12N 5/095 2010.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09Tumour cells
095Stem cells; Progenitor cells
CPC
C12N 2500/02
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2500Specific components of cell culture medium
02Atmosphere, e.g. low oxygen conditions
C12N 2501/115
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2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
115Basic fibroblast growth factor (bFGF, FGF-2)
C12N 2501/155
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2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
C12N 2501/16
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2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
16Activin; Inhibin; Mullerian inhibiting substance
C12N 2501/165
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2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
165Vascular endothelial growth factor [VEGF]
C12N 2502/1394
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2502Coculture with; Conditioned medium produced by
13connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
1394Bone marrow stromal cells; whole marrow
Applicants
  • WISCONSIN ALUMNI RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • SLUKVIN, Igor [US]/[US] (US)
  • UENISHI, Gene, Ichiro [US]/[US] (US)
Inventors
  • SLUKVIN, Igor
  • UENISHI, Gene, Ichiro
Agents
  • BAKER, Jean, C.
Priority Data
61/779,56413.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND MATERIALS FOR HEMATOENDOTHELIAL DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED CONDITIONS
(FR) MÉTHODES ET MATÉRIAUX POUR LA DIFFÉRENCIATION DE CELLULES SOUCHES PLURIPOTENTES HUMAINES EN CELLULES ENDOTHÉLIALES ET HÉMATOPOÏÉTIQUES DANS DES CONDITIONS DÉFINIES
Abstract
(EN)
Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed.
(FR)
L'invention concerne des méthodes et des compositions permettant la différenciation de cellules souches pluripotentes en cellules de lignées endothéliales et hématopoïétiques.
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