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1. WO2014164026 - PREPARATION ENHANCEMENTS AND METHODS OF USE FOR MALDI MASS SPECTROMETRY

Publication Number WO/2014/164026
Publication Date 09.10.2014
International Application No. PCT/US2014/020001
International Filing Date 03.03.2014
IPC
H01J 49/04 2006.01
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
H01J 49/16 2006.01
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
16using surface ionisation, e.g. field-, thermionic- or photo-emission
CPC
G01N 33/483
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
H01J 49/0418
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
0409Sample holders or containers
0418for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI], surface enhanced laser desorption/ionisation [SELDI] plates
H01J 49/164
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
16using surface ionisation, e.g. field-, thermionic- or photo-emission
161using photoionisation, e.g. by laser
164Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
Applicants
  • AGENA BIOSCIENCE, INC. [US]/[US]
Inventors
  • BECKER, Thomas
  • BERKENKAMP, Stefan
Agents
  • GRANT, Bruce
Priority Data
13/801,52613.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREPARATION ENHANCEMENTS AND METHODS OF USE FOR MALDI MASS SPECTROMETRY
(FR) PERFECTIONNEMENTS APPORTÉS À LA PRÉPARATION ET PROCÉDÉS D'UTILISATION POUR SPECTROMÉTRIE DE MASSE MALDI
Abstract
(EN)
Provided herein are compositions and methods useful for preparing and analyzing a sample on a substrate by matrix assisted laser desorption ionization (MALDI) mass spectrometry (MS). In some embodiments, compositions provided herein comprise a substrate, matrix and nanoparticles, and sometimes comprise one or more additives and sometimes an analyte. Compositions provided herein sometimes comprise nanoparticles that include or are made up of silicon dioxide.
(FR)
L'invention concerne des compositions et des procédés utiles pour la préparation et l'analyse d'un échantillon par spectrométrie de masse (MS) à désorption/ionisation laser assistée par matrice (MALDI). Dans certains modes de réalisation, les compositions décrites comprennent un substrat, une matrice et des nanoparticules, et parfois un ou plusieurs additifs, et parfois un analyte. Les compositions de l'invention comprennent parfois des nanoparticules qui contiennent du dioxyde de silicium ou sont constituée de dioxyde de silicium.
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