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1. WO2014162106 - NOVEL CHALCONE DERIVATIVES HAVING AN ANTI-ALLERGIC ACTIVITY

Publication Number WO/2014/162106
Publication Date 09.10.2014
International Application No. PCT/FR2014/050816
International Filing Date 04.04.2014
IPC
C07D 211/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
A61K 31/4418 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4418having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A61P 37/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 27/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
14Decongestants or antiallergics
Applicants
  • UNIVERSITE CLAUDE BERNARD LYON I [FR]/[FR]
  • HOSPICES CIVILS DE LYON [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
Inventors
  • DUMONTET, Charles
  • BOUMENDJEL, Ahcène
  • MONNERET, Guillaume
Agents
  • SARLIN, Laure
Priority Data
135309105.04.2013FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NOVEL CHALCONE DERIVATIVES HAVING AN ANTI-ALLERGIC ACTIVITY
(FR) NOUVEAUX DERIVES DE CHALCONE PRESENTANT UNE ACTIVITE ANTI-ALLERGIQUE
Abstract
(EN)
The present invention concerns compounds of formula (I); in which; - R2, R4 and R6, identical or different, represent a hydrogen, chlorine, bromine, iodine or fluorine atom, or an -OH or -O-alkyl group comprising 1 to 6 carbon atoms; -R2 and R4, identical or different, represent a hydrogen atom, or an --OH or -Q-alkyl group comprising 1 to 6 carbon atoms; in which R2' and/or R4' represent(s) a methoxy group; - n is equal to 1, 2 or 3; - X = CH2, G, S or N(R7); and - R7 represents a hydrogen atom or an alkyl group comprising 1 to 6 carbon atoms; and the pharmaceutically acceptable hydrates, solvates and salts thereof.
(FR)
La présente invention concerne les composés de formule (I); dans laquelle; - R2, R4 et R6, Identiques ou différents, représentent un atome d'hydrogène, chlore, brome, iode ou fluor, ou un groupe -OH ou -O-alkyle comprenant de 1 à 6 atomes de carbone; -R2, et R4, Identiques ou différents, représentent un atome d'hydrogène, ou un groupe --OH ou -Q-alkyle comprenant de 1 à 6 atomes de carbone; avec R2' et/ou R4' qui représente(nt) un groupe méthoxy; - n est égal à 1, 2, 3; - X = CH2, G, S ou N(R7); et - R7 représente un atome d'hydrogène ou un groupe alkyle comprenant de 1 à 6 atomes de carbone; ainsi que leurs hydrates, solvats et sels pharmaceutiquement acceptables,
Latest bibliographic data on file with the International Bureau