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1. WO2014159961 - MEASUREMENT OF FGF21 AS A BIOMARKER OF FRUCTOSE METABOLISM AND METABOLIC DISEASE

Publication Number WO/2014/159961
Publication Date 02.10.2014
International Application No. PCT/US2014/025527
International Filing Date 13.03.2014
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/74 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G01N 2333/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
475Assays involving growth factors
50Fibroblast growth factors [FGF]
G01N 2333/575
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
575Hormones
G01N 2800/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
04Endocrine or metabolic disorders
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US]/[US]
Inventors
  • MARATOS-FLIER, Eleftheria
  • HERMAN, Mark
  • DUSHAY, Jody
  • FISHER, Ffolliott Martin
Agents
  • HOGLE, Doreen, M.
Priority Data
61/781,67514.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEASUREMENT OF FGF21 AS A BIOMARKER OF FRUCTOSE METABOLISM AND METABOLIC DISEASE
(FR) MESURE DU FGF21 EN TANT QUE BIOMARQUEUR DU MÉTABOLISME DU FRUCTOSE ET MALADIE MÉTABOLIQUE
Abstract
(EN)
The invention provides, inter alia, methods of monitoring the fructose response of a subject by determining the level of fibroblast growth factor 21 (FGF21) gene expression product in a biological sample (such as a serum sample) from the subject, where the subject was previously administered a fructose bolus. The invention also provides methods of monitoring the response of a subject to a treatment for a disorder of metabolism, for discriminating fructose intolerance from other gastrointestinal disorders not associated with fructose intolerance, for identifying a subject at risk for developing a disorder of metabolism, as well as methods of treatment for a disorder of metabolism.
(FR)
L'invention concerne, entre autres, des procédés de surveillance de la réponse au fructose d'un sujet en déterminant le niveau du produit de l'expression génique du facteur de croissance des fibroblastes 21 (FGF21) dans un échantillon biologique (tel qu'un échantillon de sérum) issu du sujet, un bolus de fructose ayant préalablement été administré au sujet. L'invention concerne également des procédés pour surveiller la réponse d'un sujet à un traitement d'un trouble du métabolisme, pour différencier l'intolérance au fructose des autres dérangements gastro-intestinaux non associés avec l'intolérance au fructose, pour identifier un sujet risquant de développer un trouble du métabolisme, ainsi que des procédés de traitement d'un trouble du métabolisme.
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Latest bibliographic data on file with the International Bureau