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1. WO2014159776 - SOLID STATE FORMS OF 6-[4-[3-(R)-2-METHYLPYRROLIDINE-1-YL)-PROPOXY]PHENYL]2H-PYRIDAZINE-3-ONE HYDROCHLORIDE

Publication Number WO/2014/159776
Publication Date 02.10.2014
International Application No. PCT/US2014/025095
International Filing Date 12.03.2014
IPC
C07D 207/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
06with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • CEPHALON, INC. [US]/[US] (AllExceptUS)
  • BIERLMAIER, Stephen [US]/[US] (US)
  • HALTIWANGER, Ralph, Curtis [US]/[US] (US)
  • JACOBS, Martin, J. [US]/[US] (US)
Inventors
  • BIERLMAIER, Stephen
  • HALTIWANGER, Ralph, Curtis
  • JACOBS, Martin, J.
  • COURVOISIER, Laurent
Agents
  • WHITE, John, P.
Priority Data
61/782,21614.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SOLID STATE FORMS OF 6-[4-[3-(R)-2-METHYLPYRROLIDINE-1-YL)-PROPOXY]PHENYL]2H-PYRIDAZINE-3-ONE HYDROCHLORIDE
(FR) FORMES À L'ÉTAT SOLIDE DE CHLORHYDRATE DE 6-[4-[3-(R)-2-MÉTHYLPYRROLIDINE-1-YL)-PROPOXY]PHÉNYL]2H-PYRIDAZINE-3-ONE
Abstract
(EN)
Solid state forms of the compound 6-[ 4- 13 -((R )- 2-mefhy lpyrrolidine · 1 - yl )-propoxy | phenyl ] 2H-pyridazine-3-one hydrochloride (Compound 1), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. Compound 1 is a histamine H3 receptor antagonist / inverse agonist. Thus the provided solid state forms are useful, for example, for the manufacture of a medicament for the treatment of disorders mediated by the H3 receptor. [FORMULA SHOULD BE INSERTED HERE]
(FR)
L'invention concerne des formes à l'état solide du composé chlorhydrate de 6-[4-[3-(R)-2-méthylpyrrolidine-1-yl)-propoxy]phényl]2H-pyridazine-3-one (Composé 1), des procédés pour préparer les formes à l'état solide, et des compositions pharmaceutiques de celles-ci. Le composé 1 est un antagoniste/agoniste inverse des récepteurs d'histamine H3. Ainsi, les formes à l'état solide fournies sont utiles, par exemple, pour la fabrication d'un médicament pour le traitement de troubles dont le médiateur est le récepteur H3. [La formule doit être insérée ici]
Also published as
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