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1. WO2014159498 - AUTOMATED ANALYSIS SYSTEM FOR THE DETECTION AND SCREENING OF NEUROLOGICAL DISORDERS AND DEFICITS

Publication Number WO/2014/159498
Publication Date 02.10.2014
International Application No. PCT/US2014/023923
International Filing Date 12.03.2014
IPC
A61B 5/11 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
103Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
16Devices for psychotechnics; Testing reaction times
A61B 3/113 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
113for determining or recording eye movement
CPC
A61B 3/113
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
113for determining or recording eye movement
A61B 5/1103
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
103Detecting, measuring or recording devices for testing the shape, pattern, ; colour,; size or movement of the body or parts thereof, for diagnostic purposes
11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
1103Detecting eye twinkling
A61B 5/4076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4076Diagnosing or monitoring particular conditions of the nervous system
A61B 5/4082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4076Diagnosing or monitoring particular conditions of the nervous system
4082Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
A61B 5/4842
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4842Monitoring progression or stage of a disease
A61B 5/4848
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4848Monitoring or testing the effects of treatment, e.g. of medication
Applicants
  • VIRGINIA COMMONWEALTH UNIVERSITY [US]/[US]
Inventors
  • WETZEL, Paul, A.
  • BARON, Mark, S.
  • GITCHEL, George, T.
Agents
  • WHITHAM, Michael, E.
Priority Data
61/783,15614.03.2013US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AUTOMATED ANALYSIS SYSTEM FOR THE DETECTION AND SCREENING OF NEUROLOGICAL DISORDERS AND DEFICITS
(FR) SYSTÈME D'ANALYSE AUTOMATISÉ PRÉVU POUR LA DÉTECTION ET LE DÉPISTAGE DE TROUBLES ET DE DÉFICITS NEUROLOGIQUES
Abstract
(EN)
Objects of interest which project beyond the fovea are poorly resolved and lack color information, requiring movement of the eyes in order to obtain a comprehensive image and perception of the surrounding world. Eye movements emanate from different areas of the brain which can be affected by disease and or injury. As such, different neurological disorders will affect a myriad of eye movements in a variety of different ways. An automated system and method, capable of detecting, analyzing and summarizing a person's eye movements is used to detect (diagnose) (either before or after symptoms of said neurological disease are apparent), confirm a prior diagnosis, and/or to monitor the treatment effectiveness for a variety of neurological diseases, neurological movement disorders and potential brain injuries. The analyzed and summarized eye movements are cataloged, interpreted and utilized in a diagnostic matrix in order to highlight and distinguish abnormal eye movements, and to provide an objective clinical or pre-clinical/pre-symptomatic diagnosis based on the non-invasive testing procedures.
(FR)
Certains objets d'intérêt qui sont projetés devant la fovéa ont une résolution médiocre et manquent d'informations de couleur, ce qui nécessite un mouvement des yeux pour obtenir une image et une perception complètes du monde environnant. Les mouvements des yeux émanent de différentes zones du cerveau, lesquelles peuvent être affectées par une maladie et/ou une lésion. Ainsi, différents troubles neurologiques affecteront une myriade de mouvements des yeux de plusieurs manières différentes. La présente invention concerne un système et une méthode automatisés permettant de détecter, d'analyser et de récapituler les mouvements des yeux d'une personne, qui sont utilisés pour détecter (diagnostiquer) (soit avant soit après l'apparition de symptômes de ladite maladie neurologique), pour confirmer un diagnostic antérieur, et/ou pour surveiller l'efficacité de traitement de diverses maladies neurologiques, de troubles de mouvement neurologiques et de lésions potentielles du cerveau. Les mouvements des yeux analysés et ayant fait l'objet d'une récapitulation sont catalogués, interprétés et utilisés dans une matrice de diagnostic pour mettre en évidence et distinguer des mouvements anormaux des yeux et pour établir un diagnostic clinique ou préclinique/présymptomatique objectif sur la base des procédures de test non invasives.
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