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1. WO2014159224 - HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Publication Number WO/2014/159224
Publication Date 02.10.2014
International Application No. PCT/US2014/022597
International Filing Date 10.03.2014
IPC
A61K 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
CPC
C07C 233/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
57having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
60having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 259/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
259Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
08having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
C07C 2601/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
08the ring being saturated
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 2601/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
18with a ring being at least seven-membered
C07D 209/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
Applicants
  • CHDI FOUNDATION, INC. [US]/[US]
Inventors
  • DOMINGUEZ, Celia
  • MUÑOZ-SAN JUAN, Ignacio
  • MAILLARD, Michel
  • RAPHY, Gilles
  • HAUGHAN, Alan, F.
  • LUCKHURST, Christopher, A.
  • JARVIS, Rebecca, E.
  • BURLI, Roland, W.
  • WISHART, Grant
  • HUGHES, Samantha, J.
  • ALLEN, Daniel, R.
  • PENROSE, Stephen, D.
  • BRECCIA, Perla
Agents
  • STEVENS, Lauren, L.
Priority Data
61/785,39514.03.2013US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
(FR) INHIBITEURS D'HISTONE DÉSACÉTYLASE, ET COMPOSITIONS ET MÉTHODES D'UTILISATION ASSOCIÉES
Abstract
(EN) Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
(FR) L'invention concerne certains inhibiteurs d'histone désacétylase (HDAC) de formule I, des compositions de ceux-ci, et leurs méthodes d'utilisation.
Related patent documents
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