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1. WO2014157687 - 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE WITH ACETAMIDE GROUP

Publication Number WO/2014/157687
Publication Date 02.10.2014
International Application No. PCT/JP2014/059328
International Filing Date 28.03.2014
IPC
C07D 253/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
253Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/166
02not condensed with other rings
061,2,4-Triazines
A61K 31/53 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 37/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 253/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
253Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
02not condensed with other rings
061,2,4-Triazines
065having three double bonds between ring members or between ring members and non-ring members
07with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 253/075
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
253Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
02not condensed with other rings
061,2,4-Triazines
065having three double bonds between ring members or between ring members and non-ring members
07with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
075Two hetero atoms, in positions 3 and 5
Applicants
  • 大鵬薬品工業株式会社 TAIHO PHARMACEUTICAL CO., LTD. [JP]/[JP]
Inventors
  • 坂本 俊浩 SAKAMOTO, Toshihiro
  • 三田 隆 MITA, Takashi
  • 中村 昌幸 NAKAMURA, Masayuki
  • 荻野 悦夫 OGINO, Yoshio
  • 駒谷 秀也 KOMATANI, Hideya
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
2013-07539429.03.2013JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE WITH ACETAMIDE GROUP
(FR) DÉRIVÉ 1,2,4-TRIAZINE-6-CARBOXAMIDE AYANT UN GROUPE ACÉTAMIDE
(JA) アセトアミド基を有する1,2,4-トリアジン-6-カルボキサミド誘導体
Abstract
(EN)
Provided are novel compounds having Syk-inhibiting effects and cell growth-inhibiting effects. Also provided is a medicine that is useful for prevention and/or treatment of cancer, allergic diseases or autoimmune diseases based on Syk-inhibiting effects. Compounds represented by general formula (I) (I) (In the formula, R1 represents a hydrogen atom or C1-C6 alkyl group, etc.; R2 and R3 represent hydrogen atoms, halogen atoms, hydroxyl groups, amino groups, cyano groups, C1-C6 alkyl groups, etc. or R2, R3 and the carbon atoms to which same are bound can join together to form a C3-C10 cycloalkyl group, etc.; R4 represents a hydrogen atom or C1-C6 alkyl group, etc.; and A represents a C6-C14 aromatic hydrocarbon group or unsaturated heterocylic group, etc.), and salts thereof.
(FR)
L'invention concerne de nouveaux composés ayant des effets d'inhibition de Syk et des effets d'inhibition de la croissance cellulaire. L'invention concerne également un médicament qui est utile pour la prévention et/ou le traitement du cancer, de maladies allergiques ou de maladies auto-immunes sur la base des effets d'inhibition de Syk. L'invention concerne des composés représentés par la formule générale (I) (Dans la formule, R1 représente un atome d'hydrogène ou un groupe alkyle en C1-C6, etc. ; R2 et R3 représentent des atomes d'hydrogène, des atomes d'halogène, des groupes hydroxyle, des groupes amino, des groupes cyano, des groupes alkyle en C1-C6, etc. ou R2, R3 et les atomes de carbone auxquels ils sont liés peuvent se joindre ensemble pour former un groupe cycloalkyle en C3-C10, etc. ; R4 représente un atome d'hydrogène ou un groupe alkyle en C1-C6, etc. ; et A représente un groupe hydrocarboné aromatique en C6-C14 ou un groupe hétérocyclique insaturé, etc.) et des sels de ceux-ci.
(JA)
課題Syk阻害作用を有し、且つ細胞増殖抑制効果を有する新規な化合物を提供する。またSyk阻害作用に基づき、癌、アレルギー疾患又は自己免疫疾患の予防及び/又は治療に有用な医薬を提供する。下記一般式(I)(式中、R1 は、水素原子又はC1-C6 アルキル基等を示し;R2 及びR3 は、水素原子、ハロゲン原子、ヒドロキシル基、アミノ基、シアノ基、C1-C6 アルキル基等を示すか、R2、R3 及びそれらが結合する炭素原子と一緒になってC3-C10 シクロアルキル等を形成してもよく;R4 は、水素原子又はC1-C6 アルキル基等を示し;Aは、C6-C14 芳香族炭化水素基又は不飽和複素環基等を示す。)で表される化合物又はその塩。
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