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1. WO2014154841 - PROCESS FOR THE MANUFACTURE OF (R)-5-[2-(5,6-DIETHYLINDAN-2-YLAMINO)-1-HYDROXYETHYL]-8-HYDROXY-(1H)-QUINOLIN-2-ONE

Publication Number WO/2014/154841
Publication Date 02.10.2014
International Application No. PCT/EP2014/056229
International Filing Date 27.03.2014
IPC
C07D 215/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
24attached in position 8
26Alcohols; Ethers thereof
CPC
C07D 215/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
24attached in position 8
26Alcohols; Ethers thereof
Applicants
  • LABORATORIOS LESVI, S.L. [ES]/[ES]
Inventors
  • DALMASES BARJOAN, Pere
  • HUGUET CLOTET, Juan
  • CAPDEVILA URBANEJA, Enric
Agents
  • CARBONELL VALLÈS, Enric
Priority Data
13161410.927.03.2013EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE MANUFACTURE OF (R)-5-[2-(5,6-DIETHYLINDAN-2-YLAMINO)-1-HYDROXYETHYL]-8-HYDROXY-(1H)-QUINOLIN-2-ONE
(FR) PROCÉDÉ POUR LA FABRICATION DE (R)-5-[2-(5,6-DIÉTHYL-INDAN-2-YLAMINO)-1-HYDROXYÉTHYL]-8-HYDROXY-(1H)-QUINOLIN-2-ONE
Abstract
(EN) The present invention provides an efficient process for manufacturing (R)-5-[2-(5,6-diethyl-indan-2-yl-amino)-1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one, commonly known as indacaterol, or a pharmaceutically acceptable salt thereof, comprising intermediates of synthesis of Formula (II) and Formula (III).
(FR) La présente invention concerne un procédé efficace pour la fabrication de (R)-5-[2-(5,6-diéthyl-indan-2-yl-amino)-1-hydroxyéthyl]-8-hydroxy-(1H)-quinolin-2-one, couramment connue sous le nom d'indacatérol, ou d'un sel pharmaceutiquement acceptable de celle-ci, comprenant des intermédiaires de synthèse répondant à la formule (II) et à la formule (III).
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