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1. (WO2014153209) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2014/153209 International Application No.: PCT/US2014/029606
Publication Date: 25.09.2014 International Filing Date: 14.03.2014
IPC:
C12N 15/11 (2006.01) ,C12N 5/00 (2006.01) ,C12N 15/00 (2006.01) ,A61K 48/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
ANDES BIOTECHNOLOGIES S.A. [CL/CL]; Parque Tecnologico Zanartu Av. Zanartu Nunoa, Santiago, 1482, CL
Inventors:
BURZIO ERIZ, Luis O.; CL
BURZIO MENENDEZ, Veronica A.; CL
VILLEGAS OLAVARRIA, Jaime E.; CL
Agent:
SHOW, Matthew D.; Morrison & Foerster LLP 755 Page Mill Road Palo Alto, CA 94304-1018, US
Priority Data:
61/785,26914.03.2013US
61/790,07215.03.2013US
61/937,43807.02.2014US
Title (EN) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS
(FR) OLIGONUCLÉOTIDES ANTISENS POUR LE TRAITEMENT DE CELLULES SOUCHES CANCÉREUSES
Abstract:
(EN) The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating and preventing metastasis or relapse of a cancer in an individual previously treated for cancer with a therapy. The invention also provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating a refractory cancer (e.g., a refractory HPV-associated cancer).
(FR) L'invention concerne des oligonucléotides complémentaires à un ARN mitochondrial chimérique non codant, ainsi que des compositions et des trousses comprenant ceux-ci, et leur utilisation dans le traitement et la prévention d'une métastase ou d'une récidive d'un cancer chez un individu traité auparavant pour le cancer par une thérapie. L'invention concerne également des oligonucléotides complémentaires à un ARN mitochondrial chimérique non codant, ainsi que des compositions et des trousses comprenant ceux-ci, et leur utilisation dans le traitement d'un cancer réfractaire (par exemple un cancer réfractaire associé à HPV).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2906198EP2970970CN105229150US20160138015BR112015022308ES2708650